Gene description for ITGAX
Gene name integrin, alpha X (complement component 3 receptor 4 subunit)
Gene symbol ITGAX
Other names/aliases CD11C
SLEB6
Species Homo sapiens
 Database cross references - ITGAX
ExoCarta ExoCarta_3687
Vesiclepedia VP_3687
Entrez Gene 3687
HGNC 6152
MIM 151510
UniProt P20702  
 ITGAX identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ITGAX
Molecular Function
    integrin binding GO:0005178 IBA
    integrin binding GO:0005178 TAS
    protein binding GO:0005515 IPI
    receptor tyrosine kinase binding GO:0030971 IPI
    signaling receptor activity GO:0038023 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    cell adhesion GO:0007155 TAS
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 NAS
    integrin-mediated signaling pathway GO:0007229 IBA
    integrin-mediated signaling pathway GO:0007229 NAS
    positive regulation of cell population proliferation GO:0008284 IMP
    animal organ morphogenesis GO:0009887 TAS
    positive regulation of gene expression GO:0010628 IMP
    positive regulation of gene expression GO:0010628 ISS
    positive regulation of cell migration GO:0030335 IMP
    positive regulation of myelination GO:0031643 ISS
    cell adhesion mediated by integrin GO:0033627 IBA
    heterotypic cell-cell adhesion GO:0034113 IMP
    positive regulation of angiogenesis GO:0045766 IMP
    defense response to virus GO:0051607 IEA
    cell-cell adhesion GO:0098609 IBA
    positive regulation of endothelial tube morphogenesis GO:1905956 IMP
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integrin complex GO:0008305 IBA
    external side of plasma membrane GO:0009897 IBA
    cell surface GO:0009986 HDA
    cell surface GO:0009986 IC
    cell surface GO:0009986 IDA
    membrane GO:0016020 HDA
    secretory granule membrane GO:0030667 TAS
    integrin alphaX-beta2 complex GO:0034689 IPI
    integrin alphaX-beta2 complex GO:0034689 TAS
    tertiary granule membrane GO:0070821 TAS
    ficolin-1-rich granule membrane GO:0101003 TAS
 Experiment description of studies that identified ITGAX in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ITGAX
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C3 718
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here