Gene description for Postn
Gene name periostin, osteoblast specific factor
Gene symbol Postn
Other names/aliases A630052E07Rik
AI747096
OSF-2
Osf2
PLF
PN
peri
Species Mus musculus
 Database cross references - Postn
ExoCarta ExoCarta_50706
Vesiclepedia VP_50706
Entrez Gene 50706
UniProt Q62009  
 Postn identified in sEVs derived from the following tissue/cell type
Mov neuroglial cells 15210972    
 Gene ontology annotations for Postn
Molecular Function
    extracellular matrix structural constituent GO:0005201 RCA
    heparin binding GO:0008201 IDA
    metal ion binding GO:0046872 ISO
    metal ion binding GO:0046872 ISS
    cell adhesion molecule binding GO:0050839 IBA
Biological Process
    response to hypoxia GO:0001666 IEA
    negative regulation of cell-matrix adhesion GO:0001953 IEA
    negative regulation of cell-matrix adhesion GO:0001953 ISO
    regulation of systemic arterial blood pressure GO:0003073 IEA
    regulation of systemic arterial blood pressure GO:0003073 ISO
    cell adhesion GO:0007155 IBA
    cell adhesion GO:0007155 IDA
    cell adhesion GO:0007155 ISO
    regulation of Notch signaling pathway GO:0008593 IMP
    response to mechanical stimulus GO:0009612 IEA
    tissue development GO:0009888 IMP
    response to muscle activity GO:0014850 IEA
    positive regulation of smooth muscle cell migration GO:0014911 IEA
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    extracellular matrix organization GO:0030198 IBA
    extracellular matrix organization GO:0030198 IMP
    response to estradiol GO:0032355 IEA
    cellular response to fibroblast growth factor stimulus GO:0044344 IEA
    cellular response to vitamin K GO:0071307 IDA
    cellular response to vitamin K GO:0071307 ISO
    cellular response to tumor necrosis factor GO:0071356 IEA
    cellular response to transforming growth factor beta stimulus GO:0071560 IEA
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 IEA
    negative regulation of substrate adhesion-dependent cell spreading GO:1900025 ISO
    neuron projection extension GO:1990138 IEA
    neuron projection extension GO:1990138 ISO
    bone regeneration GO:1990523 IEA
    positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 IEA
    positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 ISO
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    trans-Golgi network GO:0005802 IEA
    trans-Golgi network GO:0005802 ISO
    extracellular matrix GO:0031012 IBA
    extracellular matrix GO:0031012 IDA
    neuromuscular junction GO:0031594 IEA
    neuromuscular junction GO:0031594 ISO
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IDA
    collagen-containing extracellular matrix GO:0062023 ISO
 Experiment description of studies that identified Postn in sEVs
1
Experiment ID 39
MISEV standards
IEM
Biophysical techniques
TSG101|HSC70|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors "Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G"
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Postn
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mmp2  
Co-fractionation Mus musculus
2 Col1a2 12843
Co-fractionation Mus musculus
3 Fancd2  
Affinity Capture-MS Mus musculus
4 Vmac  
Co-fractionation Mus musculus
5 Trappc2l  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Postn is involved
No pathways found





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