Gene description for MYOZ2
Gene name myozenin 2
Gene symbol MYOZ2
Other names/aliases C4orf5
CMH16
CS-1
Species Homo sapiens
 Database cross references - MYOZ2
ExoCarta ExoCarta_51778
Vesiclepedia VP_51778
Entrez Gene 51778
HGNC 1330
MIM 605602
UniProt Q9NPC6  
 MYOZ2 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for MYOZ2
Molecular Function
    actin binding GO:0003779 IBA
    protein binding GO:0005515 IPI
    protein phosphatase 2B binding GO:0030346 NAS
    telethonin binding GO:0031433 IBA
    telethonin binding GO:0031433 IPI
    FATZ binding GO:0051373 IBA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    skeletal muscle tissue development GO:0007519 ISS
    skeletal muscle fiber adaptation GO:0043503 ISS
    sarcomere organization GO:0045214 ISS
    negative regulation of calcineurin-NFAT signaling cascade GO:0070885 ISS
Subcellular Localization
    actin cytoskeleton GO:0015629 IBA
    sarcomere GO:0030017 TAS
    Z disc GO:0030018 IBA
    Z disc GO:0030018 ISS
    Z disc GO:0030018 NAS
 Experiment description of studies that identified MYOZ2 in sEVs
1
Experiment ID 193
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MYOZ2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLNC 2318
Affinity Capture-Western Homo sapiens
2 MBLAC1 255374
Two-hybrid Homo sapiens
3 ACTN2 88
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 ZDHHC17 23390
Two-hybrid Homo sapiens
5 DRICH1  
Two-hybrid Homo sapiens
6 ACTN1 87
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 PPP3CA 5530
Affinity Capture-Western Homo sapiens
8 EWSR1 2130
Two-hybrid Homo sapiens
9 HSPB2  
Two-hybrid Homo sapiens
10 MKRN3  
Two-hybrid Homo sapiens
11 MYB  
Two-hybrid Homo sapiens
12 RBPMS 11030
Two-hybrid Homo sapiens
13 WWOX 51741
Two-hybrid Homo sapiens
14 ACTN4 81
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 TCAP  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which MYOZ2 is involved
No pathways found





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