Gene description for Snx3
Gene name sorting nexin 3
Gene symbol Snx3
Other names/aliases SDP3
Species Mus musculus
 Database cross references - Snx3
ExoCarta ExoCarta_54198
Vesiclepedia VP_54198
Entrez Gene 54198
 Snx3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Snx3
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-5-phosphate binding GO:0010314 IDA
    protein phosphatase binding GO:0019903 ISO
    phosphatidylinositol-3-phosphate binding GO:0032266 IBA
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    phosphatidylinositol-3-phosphate binding GO:0032266 ISO
    phosphatidylinositol-3-phosphate binding GO:0032266 ISS
    phosphatidylinositol-4-phosphate binding GO:0070273 IDA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
    retromer complex binding GO:1905394 ISO
    retromer complex binding GO:1905394 ISS
Biological Process
    heme biosynthetic process GO:0006783 ISO
    response to bacterium GO:0009617 ISO
    membrane invagination GO:0010324 ISO
    positive regulation of neuron projection development GO:0010976 IMP
    protein to membrane docking GO:0022615 ISO
    protein to membrane docking GO:0022615 ISS
    regulation of Wnt signaling pathway GO:0030111 ISO
    regulation of Wnt signaling pathway GO:0030111 ISS
    endocytic recycling GO:0032456 IBA
    regulation of intracellular protein transport GO:0033157 IMP
    transferrin transport GO:0033572 IMP
    late endosome to Golgi transport GO:0034499 IBA
    negative regulation of protein catabolic process GO:0042177 ISO
    hemoglobin biosynthetic process GO:0042541 IMP
    negative regulation of viral entry into host cell GO:0046597 ISO
    negative regulation of phagocytosis GO:0050765 ISO
    negative regulation of phagocytosis GO:0050765 ISS
    negative regulation of protein transport GO:0051224 ISO
    regulation of protein metabolic process GO:0051246 IMP
    intralumenal vesicle formation GO:0070676 ISO
    negative regulation of early endosome to late endosome transport GO:2000642 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    early endosome GO:0005769 ISO
    early endosome GO:0005769 ISS
    cytosol GO:0005829 ISO
    endosome membrane GO:0010008 ISO
    endosome membrane GO:0010008 ISS
    clathrin-coated vesicle GO:0030136 ISO
    clathrin-coated vesicle GO:0030136 ISS
    retromer complex GO:0030904 IBA
    retromer complex GO:0030904 ISO
    early endosome membrane GO:0031901 IBA
    early endosome membrane GO:0031901 ISO
    early phagosome GO:0032009 ISO
    early phagosome GO:0032009 ISS
 Experiment description of studies that identified Snx3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Snx3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Snx2 67804
Co-fractionation Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Sstr3  
Proximity Label-MS Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Ankfy1 11736
Co-fractionation Mus musculus
6 Tbc1d5  
Co-fractionation Mus musculus
7 Runx2  
Affinity Capture-MS Mus musculus
8 Dctn1 13191
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Snx3 is involved
No pathways found





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