Gene description for PON3
Gene name paraoxonase 3
Gene symbol PON3
Other names/aliases -
Species Homo sapiens
 Database cross references - PON3
ExoCarta ExoCarta_5446
Vesiclepedia VP_5446
Entrez Gene 5446
HGNC 9206
MIM 602720
UniProt Q15166  
 PON3 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for PON3
Molecular Function
    aryldialkylphosphatase activity GO:0004063 IEA
    arylesterase activity GO:0004064 IBA
    arylesterase activity GO:0004064 IDA
    arylesterase activity GO:0004064 NAS
    protein homodimerization activity GO:0042803 IPI
    metal ion binding GO:0046872 IEA
    acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 IDA
Biological Process
    renal sodium ion transport GO:0003096 IEA
    response to toxic substance GO:0009636 IBA
    negative regulation of superoxide anion generation GO:0032929 IEA
    carboxylic acid catabolic process GO:0046395 IDA
    establishment of localization in cell GO:0051649 IEA
    lactone catabolic process GO:1901335 IDA
    regulation of cellular response to drug GO:2001038 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PON3 in sEVs
1
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for PON3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PON1 5444
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 HS2ST1 9653
Affinity Capture-MS Homo sapiens
3 ASIC4  
Affinity Capture-MS Homo sapiens
4 NFYC 4802
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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