Gene description for FAM63B
Gene name family with sequence similarity 63, member B
Gene symbol FAM63B
Other names/aliases -
Species Homo sapiens
 Database cross references - FAM63B
ExoCarta ExoCarta_54629
Vesiclepedia VP_54629
Entrez Gene 54629
HGNC 26954
UniProt Q8NBR6  
 FAM63B identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FAM63B
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IEA
    cysteine-type carboxypeptidase activity GO:0016807 IBA
    cysteine-type carboxypeptidase activity GO:0016807 IDA
    K48-linked polyubiquitin modification-dependent protein binding GO:0036435 IDA
    K63-linked polyubiquitin modification-dependent protein binding GO:0070530 IDA
    K11-linked polyubiquitin modification-dependent protein binding GO:0071795 IDA
    K6-linked polyubiquitin modification-dependent protein binding GO:0071796 IDA
    K48-linked deubiquitinase activity GO:1990380 IBA
    K48-linked deubiquitinase activity GO:1990380 IDA
Biological Process
    proteolysis GO:0006508 IEA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified FAM63B in sEVs
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FAM63B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 XXYLT1 152002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GNPAT 8443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PRAF2 11230
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 CTU1 90353
Affinity Capture-MS Homo sapiens
5 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GPX1 2876
Affinity Capture-MS Homo sapiens
7 PPM1B 5495
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TUBB8 347688
Affinity Capture-MS Homo sapiens
9 IKBIP 121457
Affinity Capture-MS Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
11 KCNJ11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SLC27A6  
Affinity Capture-MS Homo sapiens
13 KLC1 3831
Affinity Capture-Western Homo sapiens
14 ARL8B 55207
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PTRH2 51651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 RETSAT 54884
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CYP2J2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 NCR3LG1 374383
Affinity Capture-MS Homo sapiens
19 HSDL1 83693
Affinity Capture-MS Homo sapiens
20 CADPS  
Affinity Capture-MS Homo sapiens
21 DNAJC1 64215
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 GNA13 10672
Affinity Capture-MS Homo sapiens
23 SLC27A2 11001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 ARL13B 200894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ALG11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SLC2A8 29988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 SCCPDH 51097
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MBLAC2 153364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM63B is involved
No pathways found





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