Gene description for FAM46C
Gene name family with sequence similarity 46, member C
Gene symbol FAM46C
Other names/aliases -
Species Homo sapiens
 Database cross references - FAM46C
ExoCarta ExoCarta_54855
Vesiclepedia VP_54855
Entrez Gene 54855
HGNC 24712
MIM 613952
UniProt Q5VWP2  
 FAM46C identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FAM46C
Molecular Function
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
    poly(A) RNA polymerase activity GO:1990817 IBA
    poly(A) RNA polymerase activity GO:1990817 IDA
Biological Process
    in utero embryonic development GO:0001701 IEA
    negative regulation of cell differentiation GO:0045596 IMP
    mRNA stabilization GO:0048255 IBA
    mRNA stabilization GO:0048255 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
 Experiment description of studies that identified FAM46C in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FAM46C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLK4  
Two-hybrid Homo sapiens
2 MVP 9961
Two-hybrid Homo sapiens
3 FNDC3A 22862
Affinity Capture-Western Homo sapiens
4 TRIP6 7205
Two-hybrid Homo sapiens
5 DAZAP2  
Two-hybrid Homo sapiens
6 AP2B1 163
Two-hybrid Homo sapiens
7 SQSTM1 8878
Affinity Capture-Western Homo sapiens
8 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
9 PARK2  
Two-hybrid Homo sapiens
10 RHOXF2  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FAM46C is involved
No pathways found





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