Gene description for PRPF39
Gene name pre-mRNA processing factor 39
Gene symbol PRPF39
Other names/aliases -
Species Homo sapiens
 Database cross references - PRPF39
ExoCarta ExoCarta_55015
Vesiclepedia VP_55015
Entrez Gene 55015
HGNC 20314
MIM 614907
UniProt Q86UA1  
 PRPF39 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PRPF39
Molecular Function
    protein binding GO:0005515 IPI
    pre-mRNA 5'-splice site binding GO:0030627 IBA
Biological Process
    mRNA 5'-splice site recognition GO:0000395 IBA
Subcellular Localization
    commitment complex GO:0000243 IBA
    U1 snRNP GO:0005685 IBA
    U2-type prespliceosome GO:0071004 IBA
 Experiment description of studies that identified PRPF39 in sEVs
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PRPF39
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTSE1 51512
Two-hybrid Homo sapiens
2 Rbm14  
Two-hybrid Mus musculus
3 MYCN  
Affinity Capture-MS Homo sapiens
4 LARP4 113251
Two-hybrid Homo sapiens
5 NR4A1  
Affinity Capture-MS Homo sapiens
6 CUL3 8452
Affinity Capture-MS Homo sapiens
7 RBM22 55696
Two-hybrid Homo sapiens
8 DMRTB1  
Two-hybrid Homo sapiens
9 Ube2i  
Two-hybrid Mus musculus
10 BANP  
Two-hybrid Homo sapiens
11 QKI 9444
Two-hybrid Homo sapiens
12 Nop58 55989
Two-hybrid Mus musculus
13 CUL5 8065
Affinity Capture-MS Homo sapiens
14 P4HA1 5033
Co-fractionation Homo sapiens
15 SF1 7536
Two-hybrid Homo sapiens
16 TSEN2  
Co-fractionation Homo sapiens
17 CAND1 55832
Affinity Capture-MS Homo sapiens
18 DHX30 22907
Two-hybrid Homo sapiens
19 PRRC2B  
Two-hybrid Homo sapiens
20 FBXW11  
Affinity Capture-MS Homo sapiens
21 MBNL1 4154
Two-hybrid Homo sapiens
22 MYC  
Affinity Capture-MS Homo sapiens
23 TRNAU1AP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
24 COPB2 9276
Co-fractionation Homo sapiens
25 Srsf9  
Two-hybrid Mus musculus
26 COPS5 10987
Affinity Capture-MS Homo sapiens
27 C9orf72  
Affinity Capture-MS Homo sapiens
28 WDR44 54521
Co-fractionation Homo sapiens
29 DCAF15  
Affinity Capture-Western Homo sapiens
30 CUL2 8453
Affinity Capture-MS Homo sapiens
31 KCTD15 79047
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 ZNF318 24149
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 HDAC5 10014
Affinity Capture-MS Homo sapiens
34 CEBPA  
Protein-peptide Homo sapiens
35 FOXS1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRPF39 is involved
No pathways found





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