Gene description for NDNL2
Gene name necdin-like 2
Gene symbol NDNL2
Other names/aliases HCA4
MAGEG1
MAGEL3
NSE3
NSMCE3
Species Homo sapiens
 Database cross references - NDNL2
ExoCarta ExoCarta_56160
Vesiclepedia VP_56160
Entrez Gene 56160
HGNC 7677
MIM 608243
UniProt Q96MG7  
 NDNL2 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for NDNL2
Molecular Function
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    double-strand break repair via homologous recombination GO:0000724 NAS
    DNA repair GO:0006281 IMP
    protein sumoylation GO:0016925 NAS
    positive regulation of protein ubiquitination GO:0031398 IDA
    regulation of telomere maintenance GO:0032204 NAS
    cellular response to UV GO:0034644 IMP
    cellular response to radiation GO:0071478 IMP
    cellular response to hydroxyurea GO:0072711 IMP
    chromatin looping GO:0140588 NAS
Subcellular Localization
    chromosome, telomeric region GO:0000781 NAS
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IEA
    Smc5-Smc6 complex GO:0030915 IDA
    Smc5-Smc6 complex GO:0030915 NAS
 Experiment description of studies that identified NDNL2 in sEVs
1
Experiment ID 217
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NDNL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RIT1 6016
Negative Genetic Homo sapiens
2 KRT37 8688
Affinity Capture-MS Homo sapiens
3 SENP3 26168
Affinity Capture-MS Homo sapiens
4 USP7 7874
Affinity Capture-MS Homo sapiens
5 FANCD2  
Affinity Capture-MS Homo sapiens
6 SMC5 23137
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
7 FAS 355
Proximity Label-MS Homo sapiens
8 NSMCE2  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
9 E2F1 1869
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 Smc6  
Affinity Capture-MS Mus musculus
11 SMC6  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
12 PJA2  
Affinity Capture-MS Homo sapiens
13 OBFC1 79991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FAM178A  
Affinity Capture-MS Homo sapiens
15 SIMC1  
Affinity Capture-MS Homo sapiens
16 MAGEE1  
Affinity Capture-MS Homo sapiens
17 MAGED4B  
Affinity Capture-MS Homo sapiens
18 MRFAP1L1  
Affinity Capture-MS Homo sapiens
19 PJA1  
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
20 TRIM28 10155
Reconstituted Complex Homo sapiens
21 MAGED4  
Affinity Capture-MS Homo sapiens
22 NGFR 4804
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 EID3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
24 ZNF597  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 KRAS 3845
Negative Genetic Homo sapiens
26 NSMCE4A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
27 UBXN6 80700
Affinity Capture-MS Homo sapiens
28 NSMCE1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
View the network image/svg+xml



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