Gene description for Mpp6
Gene name membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Gene symbol Mpp6
Other names/aliases P55t
Pals2
Species Mus musculus
 Database cross references - Mpp6
ExoCarta ExoCarta_56524
Vesiclepedia VP_56524
Entrez Gene 56524
UniProt Q9JLB0  
 Mpp6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mpp6
Molecular Function
    guanylate kinase activity GO:0004385 ISS
    protein binding GO:0005515 IPI
Biological Process
    GMP metabolic process GO:0046037 IEA
    GDP metabolic process GO:0046710 IEA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IBA
    membrane GO:0016020 ISS
 Experiment description of studies that identified Mpp6 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mpp6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Pip4k2b  
Co-fractionation Mus musculus
2 NET1 10276
Protein-peptide Homo sapiens
3 Tmem173  
Proximity Label-MS Mus musculus
4 CEP128  
Affinity Capture-MS Homo sapiens
5 CORO2A  
Affinity Capture-MS Homo sapiens
6 RASIP1  
Affinity Capture-MS Homo sapiens
7 LIN7C 55327
Affinity Capture-MS Homo sapiens
8 Fancd2  
Affinity Capture-MS Mus musculus
9 RBM10  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Mpp6 is involved
No pathways found





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