Gene description for KIAA1462
Gene name KIAA1462
Gene symbol KIAA1462
Other names/aliases JCAD
Species Homo sapiens
 Database cross references - KIAA1462
ExoCarta ExoCarta_57608
Vesiclepedia VP_57608
Entrez Gene 57608
HGNC 29283
MIM 614398
UniProt Q9P266  
 KIAA1462 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for KIAA1462
Biological Process
    cell adhesion GO:0007155 IEA
    positive regulation of MAPK cascade GO:0043410 IMP
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IMP
    positive regulation of vascular endothelial growth factor signaling pathway GO:1900748 IMP
    positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 IBA
    positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 IMP
    positive regulation of sprouting angiogenesis GO:1903672 IEA
Subcellular Localization
    adherens junction GO:0005912 IBA
    adherens junction GO:0005912 IDA
    ruffle membrane GO:0032587 IBA
    ruffle membrane GO:0032587 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified KIAA1462 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KIAA1462
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CAMKV 79012
Affinity Capture-MS Homo sapiens
2 LATS1  
Proximity Label-MS Homo sapiens
3 PARD3 56288
Proximity Label-MS Homo sapiens
4 BICD1 636
Proximity Label-MS Homo sapiens
5 CDC14A  
Proximity Label-MS Homo sapiens
6 ACTB 60
Proximity Label-MS Homo sapiens
7 RNF2  
Affinity Capture-MS Homo sapiens
8 CTNNA1 1495
Proximity Label-MS Homo sapiens
9 DYNLL2 140735
Affinity Capture-MS Homo sapiens
10 NR3C1 2908
Proximity Label-MS Homo sapiens
11 CDH1 999
Proximity Label-MS Homo sapiens
12 MLLT4 4301
Proximity Label-MS Homo sapiens
13 LATS2 26524
Proximity Label-MS Homo sapiens
14 OCLN 100506658
Proximity Label-MS Homo sapiens
15 DYRK1A 1859
Affinity Capture-MS Homo sapiens
16 GBA 2629
Affinity Capture-MS Homo sapiens
17 CEP135  
Proximity Label-MS Homo sapiens
18 CXADR 1525
Proximity Label-MS Homo sapiens
19 NCKIPSD 51517
Proximity Label-MS Homo sapiens
20 CTNNB1 1499
Proximity Label-MS Homo sapiens
21 AMOT 154796
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KIAA1462 is involved
No pathways found





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