Gene description for Tmod2
Gene name tropomodulin 2
Gene symbol Tmod2
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Tmod2
ExoCarta ExoCarta_58814
Vesiclepedia VP_58814
Entrez Gene 58814
UniProt P70566  
 Tmod2 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Tmod2
Molecular Function
    actin binding GO:0003779 IDA
    tropomyosin binding GO:0005523 IBA
    tropomyosin binding GO:0005523 IDA
    tropomyosin binding GO:0005523 IEA
Biological Process
    muscle contraction GO:0006936 IBA
    actin filament organization GO:0007015 IBA
    actin filament organization GO:0007015 TAS
    neuron-neuron synaptic transmission GO:0007270 IEA
    neuron-neuron synaptic transmission GO:0007270 ISO
    learning or memory GO:0007611 IEA
    learning or memory GO:0007611 ISO
    myofibril assembly GO:0030239 IBA
    positive regulation of G protein-coupled receptor signaling pathway GO:0045745 IEA
    positive regulation of G protein-coupled receptor signaling pathway GO:0045745 ISO
    pointed-end actin filament capping GO:0051694 IEA
Subcellular Localization
    cytoskeleton GO:0005856 IBA
    cytoskeleton GO:0005856 IEA
    striated muscle thin filament GO:0005865 IBA
    myofibril GO:0030016 IBA
    growth cone GO:0030426 IDA
    synapse GO:0045202 IEA
 Experiment description of studies that identified Tmod2 in sEVs
1
Experiment ID 100
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 101
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Tmod2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Tmod2 is involved
PathwayEvidenceSource
Muscle contraction IEA Reactome
Striated Muscle Contraction IEA Reactome





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