Gene description for REST
Gene name	RE1-silencing transcription factor
Gene symbol	REST
Other names/aliases	NRSF XBR
Species	Homo sapiens
Database cross references - REST
ExoCarta	ExoCarta_5978
Vesiclepedia	VP_5978
Entrez Gene	5978
HGNC	9966
MIM	600571
UniProt	Q13127
REST identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for REST

Molecular Function     transcription cis-regulatory region binding GO:0000976 IBA     transcription cis-regulatory region binding GO:0000976 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP     RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IMP     chromatin binding GO:0003682 ISS     DNA-binding transcription factor activity GO:0003700 IDA     protein binding GO:0005515 IPI     identical protein binding GO:0042802 ISS     metal ion binding GO:0046872 IEA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 TAS     regulation of alternative mRNA splicing, via spliceosome GO:0000381 ISS     response to hypoxia GO:0001666 IDA     hematopoietic progenitor cell differentiation GO:0002244 IEA     response to ischemia GO:0002931 ISS     chromatin remodeling GO:0006338 ISS     regulation of DNA-templated transcription GO:0006355 IDA     regulation of DNA-templated transcription GO:0006355 NAS     negative regulation of cell population proliferation GO:0008285 IMP     positive regulation of gene expression GO:0010628 ISS     negative regulation of gene expression GO:0010629 IMP     negative regulation of gene expression GO:0010629 ISS     negative regulation of aldosterone biosynthetic process GO:0032348 IMP     cellular response to stress GO:0033554 IEA     somatic stem cell population maintenance GO:0035019 ISS     positive regulation of apoptotic process GO:0043065 IMP     positive regulation of programmed cell death GO:0043068 ISS     negative regulation by host of viral transcription GO:0043922 IDA     negative regulation of neuron differentiation GO:0045665 IBA     negative regulation of neuron differentiation GO:0045665 IDA     negative regulation of neuron differentiation GO:0045665 IMP     positive regulation of neuron differentiation GO:0045666 ISS     regulation of osteoblast differentiation GO:0045667 ISS     negative regulation of DNA-templated transcription GO:0045892 IBA     negative regulation of DNA-templated transcription GO:0045892 IDA     negative regulation of DNA-templated transcription GO:0045892 IMP     negative regulation of DNA-templated transcription GO:0045892 NAS     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     negative regulation of calcium ion-dependent exocytosis GO:0045955 ISS     negative regulation of insulin secretion GO:0046676 IMP     negative regulation of neurogenesis GO:0050768 ISS     nervous system process GO:0050877 IMP     neuromuscular process controlling balance GO:0050885 ISS     detection of mechanical stimulus involved in sensory perception of sound GO:0050910 ISS     auditory receptor cell stereocilium organization GO:0060088 ISS     cardiac muscle cell myoblast differentiation GO:0060379 ISS     cellular response to electrical stimulus GO:0071257 IMP     cellular response to glucocorticoid stimulus GO:0071385 IDA     cellular response to xenobiotic stimulus GO:0071466 IMP     neuronal stem cell population maintenance GO:0097150 ISS     modification of synaptic structure GO:0099563 ISS     positive regulation of stem cell population maintenance GO:1902459 IDA     negative regulation of miRNA transcription GO:1902894 IMP     negative regulation of cortisol biosynthetic process GO:2000065 IMP     negative regulation of dense core granule biogenesis GO:2000706 ISS     negative regulation of mesenchymal stem cell differentiation GO:2000740 IMP     negative regulation of amniotic stem cell differentiation GO:2000798 IMP     positive regulation of cysteine-type endopeptidase activity GO:2001056 IMP Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IMP     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IDA     transcription repressor complex GO:0017053 IBA     transcription repressor complex GO:0017053 IDA