Gene description for Lmna
Gene name lamin A/C
Gene symbol Lmna
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lmna
ExoCarta ExoCarta_60374
Vesiclepedia VP_60374
Entrez Gene 60374
 Lmna identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
 Gene ontology annotations for Lmna
Molecular Function
    structural constituent of cytoskeleton GO:0005200 IBA
    protein binding GO:0005515 IPI
    protein phosphatase 1 binding GO:0008157 IPI
    identical protein binding GO:0042802 ISO
    structural constituent of nuclear lamina GO:0160123 IEA
    structural constituent of nuclear lamina GO:0160123 ISO
    structural constituent of nuclear lamina GO:0160123 ISS
Biological Process
    protein import into nucleus GO:0006606 IEA
    protein import into nucleus GO:0006606 ISO
    nucleus organization GO:0006997 ISO
    nuclear envelope organization GO:0006998 IBA
    nuclear envelope organization GO:0006998 IEA
    nuclear envelope organization GO:0006998 ISO
    nuclear envelope organization GO:0006998 ISO
    nuclear envelope organization GO:0006998 ISS
    nuclear migration GO:0007097 IBA
    spermatogenesis GO:0007283 IEP
    muscle organ development GO:0007517 ISO
    protein localization GO:0008104 ISO
    negative regulation of cell population proliferation GO:0008285 ISO
    response to mechanical stimulus GO:0009612 IEP
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of gene expression GO:0010628 ISO
    regulation of cell migration GO:0030334 IEA
    regulation of cell migration GO:0030334 ISO
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 IEA
    establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 ISO
    heterochromatin formation GO:0031507 IBA
    regulation of protein stability GO:0031647 IEA
    regulation of protein stability GO:0031647 ISO
    regulation of telomere maintenance GO:0032204 ISO
    protein localization to nucleus GO:0034504 ISO
    protein localization to nucleus GO:0034504 ISO
    protein localization to nucleus GO:0034504 ISS
    positive regulation of osteoblast differentiation GO:0045669 IMP
    nuclear pore localization GO:0051664 IBA
    ventricular cardiac muscle cell development GO:0055015 IEA
    ventricular cardiac muscle cell development GO:0055015 ISO
    cellular response to hypoxia GO:0071456 IEA
    cellular response to hypoxia GO:0071456 ISO
    negative regulation of mesenchymal cell proliferation GO:0072201 IEA
    negative regulation of mesenchymal cell proliferation GO:0072201 ISO
    negative regulation of release of cytochrome c from mitochondria GO:0090201 IEA
    negative regulation of release of cytochrome c from mitochondria GO:0090201 ISO
    cellular senescence GO:0090398 IEA
    cellular senescence GO:0090398 IEP
    cellular senescence GO:0090398 ISO
    cellular senescence GO:0090398 ISS
    protein localization to nuclear envelope GO:0090435 IBA
    regulation of protein localization to nucleus GO:1900180 IEA
    regulation of protein localization to nucleus GO:1900180 ISO
    negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 IEA
    negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 ISO
    negative regulation of cardiac muscle hypertrophy in response to stress GO:1903243 ISS
    negative regulation of adipose tissue development GO:1904178 IMP
    DNA double-strand break attachment to nuclear envelope GO:1990683 IEA
    DNA double-strand break attachment to nuclear envelope GO:1990683 ISO
    DNA double-strand break attachment to nuclear envelope GO:1990683 ISS
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nuclear envelope GO:0005635 IBA
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 IEA
    nuclear envelope GO:0005635 ISO
    nuclear envelope GO:0005635 ISS
    lamin filament GO:0005638 IEA
    lamin filament GO:0005638 ISO
    nuclear lamina GO:0005652 IBA
    nuclear lamina GO:0005652 IEA
    nuclear lamina GO:0005652 ISO
    nuclear lamina GO:0005652 ISS
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleoplasm GO:0005654 ISS
    intermediate filament GO:0005882 IEA
    nuclear matrix GO:0016363 IDA
    nuclear matrix GO:0016363 IEA
    nuclear matrix GO:0016363 ISO
    nuclear speck GO:0016607 IEA
    nuclear speck GO:0016607 ISO
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
    site of double-strand break GO:0035861 IEA
    site of double-strand break GO:0035861 ISO
    site of double-strand break GO:0035861 ISS
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Lmna in sEVs
1
Experiment ID 225
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 225
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
3
Experiment ID 96
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Lmna
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sumo3  
Affinity Capture-MS Rattus norvegicus
2 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Lmna is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here