Gene description for PPIAL4A
Gene name peptidylprolyl isomerase A (cyclophilin A)-like 4A
Gene symbol PPIAL4A
Other names/aliases COAS-2
COAS2
PPIAL4
PPIAL4B
Species Homo sapiens
 Database cross references - PPIAL4A
ExoCarta ExoCarta_653505
Vesiclepedia VP_653505
Entrez Gene 653505
HGNC 24369
UniProt Q9Y536  
 PPIAL4A identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for PPIAL4A
Molecular Function
    peptidyl-prolyl cis-trans isomerase activity GO:0003755 IBA
    cyclosporin A binding GO:0016018 IBA
    RNA polymerase II CTD heptapeptide repeat P3 isomerase activity GO:0140839 IEA
    RNA polymerase II CTD heptapeptide repeat P6 isomerase activity GO:0140840 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein folding GO:0006457 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified PPIAL4A in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for PPIAL4A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DUSP9  
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 NUDCD2 134492
Co-fractionation Homo sapiens
4 SOAT1 6646
Affinity Capture-MS Homo sapiens
5 SOD1 6647
Affinity Capture-MS Homo sapiens
6 KIF23 9493
Affinity Capture-MS Homo sapiens
7 DLST 1743
Affinity Capture-MS Homo sapiens
8 SDHA 6389
Affinity Capture-MS Homo sapiens
9 SOX2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPIAL4A is involved
No pathways found





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