Gene description for Trip13
Gene name thyroid hormone receptor interactor 13
Gene symbol Trip13
Other names/aliases 2410002G23Rik
D13Ertd328e
Species Mus musculus
 Database cross references - Trip13
ExoCarta ExoCarta_69716
Vesiclepedia VP_69716
Entrez Gene 69716
UniProt Q3UA06  
 Trip13 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Trip13
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    oocyte maturation GO:0001556 IGI
    oocyte maturation GO:0001556 IMP
    double-strand break repair GO:0006302 IMP
    double-strand break repair GO:0006302 IMP
    mitotic spindle assembly checkpoint signaling GO:0007094 ISO
    mitotic spindle assembly checkpoint signaling GO:0007094 ISS
    synaptonemal complex assembly GO:0007130 IMP
    reciprocal meiotic recombination GO:0007131 IBA
    reciprocal meiotic recombination GO:0007131 IMP
    reciprocal meiotic recombination GO:0007131 IMP
    male meiosis I GO:0007141 IMP
    female meiosis I GO:0007144 IMP
    spermatogenesis GO:0007283 IMP
    spermatid development GO:0007286 IMP
    oogenesis GO:0048477 IMP
    meiotic recombination checkpoint signaling GO:0051598 IBA
Subcellular Localization
    male germ cell nucleus GO:0001673 IDA
    nucleus GO:0005634 IBA
    chromosome GO:0005694 IBA
 Experiment description of studies that identified Trip13 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Trip13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Preb  
Two-hybrid Mus musculus
3 Chd4 107932
Two-hybrid Mus musculus
View the network image/svg+xml
 Pathways in which Trip13 is involved
No pathways found





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