Gene description for FZD5
Gene name	frizzled class receptor 5
Gene symbol	FZD5
Other names/aliases	C2orf31 HFZ5
Species	Homo sapiens
Database cross references - FZD5
ExoCarta	ExoCarta_7855
Vesiclepedia	VP_7855
Entrez Gene	7855
HGNC	4043
MIM	601723
UniProt	Q13467
FZD5 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for FZD5

Molecular Function     amyloid-beta binding GO:0001540 IPI     amyloid-beta binding GO:0001540 TAS     G protein-coupled receptor activity GO:0004930 IEA     protein binding GO:0005515 IPI     lipid binding GO:0008289 IEA     Wnt-protein binding GO:0017147 IBA     Wnt-protein binding GO:0017147 IDA     Wnt-protein binding GO:0017147 IPI     Wnt-protein binding GO:0017147 TAS     protein kinase binding GO:0019901 IPI     ubiquitin protein ligase binding GO:0031625 IPI     Wnt receptor activity GO:0042813 IBA     Wnt receptor activity GO:0042813 IC     Wnt receptor activity GO:0042813 IDA     Wnt receptor activity GO:0042813 TAS     protein-containing complex binding GO:0044877 IPI Biological Process     embryonic axis specification GO:0000578 IDA     angiogenesis GO:0001525 IEA     eye development GO:0001654 IMP     glandular epithelial cell maturation GO:0002071 IEA     positive regulation of T cell cytokine production GO:0002726 IDA     G protein-coupled receptor signaling pathway GO:0007186 IEA     synapse assembly GO:0007416 TAS     negative regulation of cell population proliferation GO:0008285 IEA     anterior/posterior axis specification, embryo GO:0008595 IDA     neuron differentiation GO:0030182 ISS     post-embryonic camera-type eye development GO:0031077 IEA     positive regulation of type II interferon production GO:0032729 IMP     positive regulation of interleukin-1 beta production GO:0032731 ISS     positive regulation of tumor necrosis factor production GO:0032760 ISS     T cell differentiation in thymus GO:0033077 IEA     non-canonical Wnt signaling pathway GO:0035567 IBA     non-canonical Wnt signaling pathway GO:0035567 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     embryonic camera-type eye morphogenesis GO:0048596 IEA     Spemann organizer formation GO:0060061 IDA     canonical Wnt signaling pathway GO:0060070 IBA     canonical Wnt signaling pathway GO:0060070 IDA     canonical Wnt signaling pathway GO:0060070 IMP     apoptotic process involved in morphogenesis GO:0060561 IEA     intestinal epithelial cell maturation GO:0060574 IEA     branching involved in labyrinthine layer morphogenesis GO:0060670 IEA     syncytiotrophoblast cell differentiation involved in labyrinthine layer development GO:0060715 IEA     labyrinthine layer blood vessel development GO:0060716 IEA     chorionic trophoblast cell differentiation GO:0060718 IEA     cellular response to molecule of bacterial origin GO:0071219 IDA     regulation of chorionic trophoblast cell proliferation GO:1901382 IEA     regulation of mitophagy GO:1901524 HMP     positive regulation of protein targeting to mitochondrion GO:1903955 HMP     regulation of bicellular tight junction assembly GO:2000810 IEA Subcellular Localization     Golgi membrane GO:0000139 IEA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     bicellular tight junction GO:0005923 IEA     cell surface GO:0009986 IDA     axon GO:0030424 IEA     dendrite GO:0030425 IEA     clathrin-coated endocytic vesicle membrane GO:0030669 TAS     early endosome membrane GO:0031901 TAS     perikaryon GO:0043204 IEA     synapse GO:0045202 IEA     perinuclear region of cytoplasm GO:0048471 IEA