Gene description for GDPD3
Gene name glycerophosphodiester phosphodiesterase domain containing 3
Gene symbol GDPD3
Other names/aliases GDE7
Species Homo sapiens
 Database cross references - GDPD3
ExoCarta ExoCarta_79153
Vesiclepedia VP_79153
Entrez Gene 79153
HGNC 28638
MIM 616318
UniProt Q7L5L3  
 GDPD3 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GDPD3
Molecular Function
    lysophospholipase activity GO:0004622 IBA
    phosphoric diester hydrolase activity GO:0008081 IBA
    phosphoric diester hydrolase activity GO:0008081 IMP
    metal ion binding GO:0046872 IEA
Biological Process
    phosphatidylcholine catabolic process GO:0034638 IEA
    glycerophospholipid catabolic process GO:0046475 IBA
    N-acylethanolamine metabolic process GO:0070291 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IMP
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 ISS
    perinuclear region of cytoplasm GO:0048471 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified GDPD3 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GDPD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PCGF6  
Affinity Capture-MS Homo sapiens
2 CCDC103  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NT5C1A  
Affinity Capture-MS Homo sapiens
4 SH2D3A  
Affinity Capture-MS Homo sapiens
5 TBC1D22B  
Affinity Capture-MS Homo sapiens
6 MBD4  
Affinity Capture-MS Homo sapiens
7 PCP4  
Affinity Capture-MS Homo sapiens
8 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
9 NPPA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ZC3HC1  
Affinity Capture-MS Homo sapiens
11 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 PTDSS1 9791
Affinity Capture-MS Homo sapiens
13 ST7  
Affinity Capture-MS Homo sapiens
14 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
15 ERCC3  
Affinity Capture-MS Homo sapiens
16 PEMT  
Affinity Capture-MS Homo sapiens
17 PI4KAP1  
Affinity Capture-MS Homo sapiens
18 KDELR2 11014
Affinity Capture-MS Homo sapiens
19 SARAF  
Affinity Capture-MS Homo sapiens
20 AIRE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PINK1  
Affinity Capture-MS Homo sapiens
22 E2F6 1876
Affinity Capture-MS Homo sapiens
23 ANXA9  
Affinity Capture-MS Homo sapiens
24 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PLD5  
Affinity Capture-MS Homo sapiens
26 CUL2 8453
Affinity Capture-MS Homo sapiens
27 UPK1A 11045
Affinity Capture-MS Homo sapiens
28 GABPA 2551
Affinity Capture-MS Homo sapiens
29 CCR1  
Affinity Capture-MS Homo sapiens
30 STX17 55014
Affinity Capture-MS Homo sapiens
31 RIPPLY3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which GDPD3 is involved
PathwayEvidenceSource
Glycerophospholipid catabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of lipids IEA Reactome
Phospholipid metabolism IEA Reactome
PI Metabolism IEA Reactome





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