Gene description for TBL1XR1
Gene name transducin (beta)-like 1 X-linked receptor 1
Gene symbol TBL1XR1
Other names/aliases C21
DC42
IRA1
TBLR1
Species Homo sapiens
 Database cross references - TBL1XR1
ExoCarta ExoCarta_79718
Vesiclepedia VP_79718
Entrez Gene 79718
HGNC 29529
MIM 608628
UniProt Q9BZK7  
 TBL1XR1 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for TBL1XR1
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    transcription cis-regulatory region binding GO:0000976 ISS
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IDA
    transcription corepressor activity GO:0003714 IGI
    protein binding GO:0005515 IPI
    beta-catenin binding GO:0008013 IPI
    histone binding GO:0042393 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    blastocyst hatching GO:0001835 IEA
    response to dietary excess GO:0002021 IEA
    chromatin organization GO:0006325 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    lipid catabolic process GO:0016042 IEA
    multicellular organism growth GO:0035264 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISS
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    white fat cell differentiation GO:0050872 IEA
    fat pad development GO:0060613 IEA
    regulation of triglyceride metabolic process GO:0090207 IEA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IMP
Subcellular Localization
    histone deacetylase complex GO:0000118 IBA
    histone deacetylase complex GO:0000118 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    transcription repressor complex GO:0017053 IDA
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified TBL1XR1 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBL1XR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Kif19a  
Affinity Capture-MS Mus musculus
2 HIST2H2BE 8349
Reconstituted Complex Homo sapiens
3 HDAC4  
Affinity Capture-MS Homo sapiens
4 NFIB  
Proximity Label-MS Homo sapiens
5 THRB 7068
Affinity Capture-MS Homo sapiens
6 SKI 6497
Affinity Capture-Western Homo sapiens
7 SP1  
Co-fractionation Homo sapiens
8 ABCF1 23
Co-fractionation Homo sapiens
9 RBX1 9978
Affinity Capture-Western Homo sapiens
10 C9orf78 51759
Affinity Capture-MS Homo sapiens
11 CCDC9  
Affinity Capture-MS Homo sapiens
12 SMARCD2 6603
Co-fractionation Homo sapiens
13 SOX2  
Affinity Capture-MS Homo sapiens
14 ARNTL  
Affinity Capture-MS Homo sapiens
15 KIAA1429 25962
Affinity Capture-MS Homo sapiens
16 CAPZB 832
Affinity Capture-MS Homo sapiens
17 PARK2  
Affinity Capture-MS Homo sapiens
18 HDAC3 8841
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
19 NCOR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
20 TRIM28 10155
Affinity Capture-MS Homo sapiens
21 HR  
Affinity Capture-MS Homo sapiens
22 CDK2AP1  
Affinity Capture-MS Homo sapiens
23 GUSBP5  
Affinity Capture-MS Homo sapiens
24 Jup 16480
Affinity Capture-MS Mus musculus
25 TULP3 7289
Affinity Capture-MS Homo sapiens
26 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
27 Gspt1 14852
Affinity Capture-MS Mus musculus
28 IL17RA 23765
Affinity Capture-MS Homo sapiens
29 SMARCB1 6598
Co-fractionation Homo sapiens
30 HIST2H4A 8370
Reconstituted Complex Homo sapiens
31 METTL10  
Affinity Capture-MS Homo sapiens
32 BAG5 9529
Affinity Capture-MS Homo sapiens
33 UBE2E3 10477
Affinity Capture-Western Homo sapiens
34 IRS4 8471
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
35 LMNB1 4001
Co-fractionation Homo sapiens
36 FOXC1  
Affinity Capture-MS Homo sapiens
37 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
38 TLX3  
Proximity Label-MS Homo sapiens
39 EMD 2010
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
40 FKBP6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CUL4B 8450
Affinity Capture-Western Homo sapiens
42 QPRT 23475
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 EIF2A 83939
Co-fractionation Homo sapiens
44 UBE2I 7329
Biochemical Activity Homo sapiens
45 PPARG 5468
Proximity Label-MS Homo sapiens
46 SERPINC1 462
Affinity Capture-MS Homo sapiens
47 HAO2  
Affinity Capture-MS Homo sapiens
48 OGT 8473
Reconstituted Complex Homo sapiens
49 FOXK2  
Affinity Capture-MS Homo sapiens
50 ACTL6A 86
Co-fractionation Homo sapiens
51 TAB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
52 Bag2  
Affinity Capture-MS Mus musculus
53 TGM1 7051
Affinity Capture-MS Homo sapiens
54 GATA2  
Proximity Label-MS Homo sapiens
55 HDAC5 10014
Affinity Capture-MS Homo sapiens
56 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
57 ARID4A  
Co-fractionation Homo sapiens
58 GPS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SMARCC2 6601
Co-fractionation Homo sapiens
60 NTRK1 4914
Affinity Capture-MS Homo sapiens
61 PSMA3 5684
Affinity Capture-MS Homo sapiens
62 DGKG  
Affinity Capture-MS Homo sapiens
63 XPO1 7514
Affinity Capture-MS Homo sapiens
64 SMARCD1 6602
Co-fractionation Homo sapiens
65 BAG2 9532
Affinity Capture-MS Homo sapiens
66 CCL26  
Affinity Capture-MS Homo sapiens
67 IKZF3  
Affinity Capture-MS Homo sapiens
68 NCAPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 CD2BP2 10421
Co-fractionation Homo sapiens
70 TTC29  
Affinity Capture-MS Homo sapiens
71 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
72 MECP2 4204
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
73 GATA3  
Proximity Label-MS Homo sapiens
74 BCL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
75 IKZF1  
Affinity Capture-MS Homo sapiens
76 THRA  
Affinity Capture-MS Homo sapiens
77 MKX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 KSR2  
Affinity Capture-MS Homo sapiens
79 CYP2J2  
Affinity Capture-MS Homo sapiens
80 NHP2L1 4809
Co-fractionation Homo sapiens
81 TBL1X 6907
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
82 DDB1 1642
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
83 RNF2  
Affinity Capture-MS Homo sapiens
84 CCND1 595
Co-fractionation Homo sapiens
85 FOXK1 221937
Affinity Capture-MS Homo sapiens
86 FHL2 2274
Affinity Capture-MS Homo sapiens
87 GBAP1  
Affinity Capture-MS Homo sapiens
88 PPIF 10105
Co-fractionation Homo sapiens
89 UBE2D1 7321
Affinity Capture-Western Homo sapiens
90 ARL2 402
Two-hybrid Homo sapiens
91 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
92 RARA 5914
Affinity Capture-Western Homo sapiens
93 Tmod3 50875
Affinity Capture-MS Mus musculus
94 SIRT6  
Affinity Capture-MS Homo sapiens
95 SMARCC1 6599
Co-fractionation Homo sapiens
96 SAP18 10284
Co-fractionation Homo sapiens
97 ZNF276 92822
Affinity Capture-MS Homo sapiens
98 USP44  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
99 Setd5 72895
Affinity Capture-MS Mus musculus
100 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
101 CHD4 1108
Co-fractionation Homo sapiens
102 TSC22D4 81628
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 ESR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
104 PPP4R1L  
Affinity Capture-MS Homo sapiens
105 KDM1A 23028
Affinity Capture-MS Homo sapiens
106 TBL1Y  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 ERF  
Affinity Capture-MS Homo sapiens
108 METTL3  
Affinity Capture-MS Homo sapiens
109 WDR59 79726
Affinity Capture-MS Homo sapiens
110 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
111 NFIC 4782
Proximity Label-MS Homo sapiens
112 AR 367
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
113 SMARCD3  
Co-fractionation Homo sapiens
114 SSRP1 6749
Affinity Capture-MS Homo sapiens
115 CCT8L2  
Affinity Capture-MS Homo sapiens
116 SP7  
Proximity Label-MS Homo sapiens
117 NOTCH1 4851
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TBL1XR1 is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) TAS Reactome
Adipogenesis TAS Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression IEA Reactome
Cellular response to chemical stress TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress IEA Reactome
Cellular responses to stress TAS Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Circadian Clock IEA Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants TAS Reactome
Cytoprotection by HMOX1 TAS Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Disorders of Developmental Biology IEA Reactome
Disorders of Nervous System Development IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HDACs deacetylate histones TAS Reactome
Heme signaling IEA Reactome
Infectious disease TAS Reactome
Loss of function of MECP2 in Rett syndrome IEA Reactome
Loss of MECP2 binding ability to the NCoR/SMRT complex IEA Reactome
Metabolism TAS Reactome
Metabolism IEA Reactome
Metabolism of lipids TAS Reactome
Metabolism of lipids IEA Reactome
Metabolism of steroids TAS Reactome
Mitochondrial biogenesis TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
Notch-HLH transcription pathway TAS Reactome
NOTCH1 Intracellular Domain Regulates Transcription IEA Reactome
NR1H2 and NR1H3-mediated signaling TAS Reactome
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux TAS Reactome
Organelle biogenesis and maintenance TAS Reactome
Pervasive developmental disorders IEA Reactome
PPARA activates gene expression TAS Reactome
PPARA activates gene expression IEA Reactome
Regulation of cholesterol biosynthesis by SREBP (SREBF) TAS Reactome
Regulation of lipid metabolism by PPARalpha TAS Reactome
Regulation of lipid metabolism by PPARalpha IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RORA activates gene expression IEA Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 in Cancer TAS Reactome
Signaling by NOTCH1 PEST Domain Mutants in Cancer TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Transcriptional activation of mitochondrial biogenesis TAS Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transcriptional regulation of white adipocyte differentiation TAS Reactome
Viral Infection Pathways TAS Reactome





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