Gene description for TRIM46
Gene name tripartite motif containing 46
Gene symbol TRIM46
Other names/aliases GENEY
TRIFIC
Species Homo sapiens
 Database cross references - TRIM46
ExoCarta ExoCarta_80128
Vesiclepedia VP_80128
Entrez Gene 80128
HGNC 19019
MIM 600986
UniProt Q7Z4K8  
 TRIM46 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TRIM46
Molecular Function
    zinc ion binding GO:0008270 IEA
Biological Process
    microtubule bundle formation GO:0001578 IBA
    neuron migration GO:0001764 IBA
    axonogenesis GO:0007409 IBA
    negative regulation of axon extension GO:0030517 ISS
    regulation of protein localization GO:0032880 ISS
    anterograde synaptic vesicle transport GO:0048490 IBA
    protein localization to axon GO:0099612 IEA
    positive regulation of anterograde dense core granule transport GO:1901953 ISS
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    axon initial segment GO:0043194 IEA
    main axon GO:0044304 IBA
    main axon GO:0044304 ISS
    axon cytoplasm GO:1904115 IEA
    proximal neuron projection GO:1990769 IEA
 Experiment description of studies that identified TRIM46 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TRIM46
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 USP2  
Two-hybrid Homo sapiens
2 TK1 7083
Two-hybrid Homo sapiens
3 USP15 9958
Two-hybrid Homo sapiens
4 MTNR1B  
Two-hybrid Homo sapiens
5 UBE2Z 65264
Two-hybrid Homo sapiens
6 USP1 7398
Two-hybrid Homo sapiens
7 BRCA1 672
Two-hybrid Homo sapiens
8 PHLPP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 TSG101 7251
Two-hybrid Homo sapiens
10 TRIM9  
Two-hybrid Homo sapiens
11 MDM4  
Two-hybrid Homo sapiens
12 APP 351
Reconstituted Complex Homo sapiens
13 RNF7  
Two-hybrid Homo sapiens
14 APEX1 328
Affinity Capture-RNA Homo sapiens
15 UBE2D2 7322
Reconstituted Complex Homo sapiens
16 OTUD6A  
Two-hybrid Homo sapiens
17 NTRK1 4914
Affinity Capture-MS Homo sapiens
18 AK5 26289
Two-hybrid Homo sapiens
19 RNF125  
Two-hybrid Homo sapiens
20 UCHL5 51377
Two-hybrid Homo sapiens
21 UBE2U  
Two-hybrid Homo sapiens
22 USP32 84669
Two-hybrid Homo sapiens
23 CBLC  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TRIM46 is involved
PathwayEvidenceSource
Cytokine Signaling in Immune system TAS Reactome
Immune System TAS Reactome
Interferon gamma signaling TAS Reactome
Interferon Signaling TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here