Gene description for CXXC4
Gene name CXXC finger protein 4
Gene symbol CXXC4
Other names/aliases IDAX
Species Homo sapiens
 Database cross references - CXXC4
ExoCarta ExoCarta_80319
Vesiclepedia VP_80319
Entrez Gene 80319
HGNC 24593
MIM 611645
 CXXC4 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CXXC4
Molecular Function
    zinc ion binding GO:0008270 IDA
    methyl-CpG binding GO:0008327 IBA
    methyl-CpG binding GO:0008327 IDA
    PDZ domain binding GO:0030165 IPI
Biological Process
    zygotic specification of dorsal/ventral axis GO:0007352 ISS
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of Wnt signaling pathway GO:0030178 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IDA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified CXXC4 in sEVs
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CXXC4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 APOD 347
Affinity Capture-MS Homo sapiens
3 PUS7 54517
Affinity Capture-MS Homo sapiens
4 FBXO25  
Two-hybrid Homo sapiens
5 ZNFX1 57169
Affinity Capture-MS Homo sapiens
6 TIA1 7072
Affinity Capture-MS Homo sapiens
7 FOXL2  
Affinity Capture-Western Homo sapiens
8 RCVRN  
Affinity Capture-MS Homo sapiens
9 BRD9 65980
Affinity Capture-MS Homo sapiens
10 RAD51  
Affinity Capture-MS Homo sapiens
11 GPN3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CXXC4 is involved
No pathways found





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