Gene description for CAMK4
Gene name calcium/calmodulin-dependent protein kinase IV
Gene symbol CAMK4
Other names/aliases CaMK IV
CaMK-GR
IV
caMK
Species Homo sapiens
 Database cross references - CAMK4
ExoCarta ExoCarta_814
Vesiclepedia VP_814
Entrez Gene 814
HGNC 1464
MIM 114080
UniProt Q16566  
 CAMK4 identified in sEVs derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for CAMK4
Molecular Function
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IDA
    calmodulin binding GO:0005516 IBA
    ATP binding GO:0005524 IEA
    calcium-dependent protein serine/threonine kinase activity GO:0009931 IBA
    protein serine kinase activity GO:0106310 IEA
Biological Process
    adaptive immune response GO:0002250 IEA
    positive regulation of myeloid dendritic cell cytokine production GO:0002735 IMP
    protein phosphorylation GO:0006468 TAS
    inflammatory response GO:0006954 IEA
    signal transduction GO:0007165 TAS
    long-term memory GO:0007616 IGI
    regulation of T cell differentiation in thymus GO:0033081 TAS
    intracellular signal transduction GO:0035556 IBA
    myeloid dendritic cell differentiation GO:0043011 IMP
    regulation of osteoclast differentiation GO:0045670 TAS
    positive regulation of DNA-templated transcription GO:0045893 IDA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CAMK4 in sEVs
1
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CAMK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARHGEF7 8874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 GYPA  
Affinity Capture-MS Homo sapiens
3 HDAC4  
Biochemical Activity Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 LGI1  
Affinity Capture-MS Homo sapiens
6 NEDD4 4734
Reconstituted Complex Homo sapiens
7 RBPJ 3516
Affinity Capture-Western Homo sapiens
8 GIT2 9815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CABIN1  
Biochemical Activity Homo sapiens
10 PPP6R2 9701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 METTL21B  
Affinity Capture-MS Homo sapiens
12 ANKRD28 23243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
14 CUL9  
Affinity Capture-MS Homo sapiens
15 ANKRD52 283373
Affinity Capture-MS Homo sapiens
16 GIT1 28964
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
18 CUL7 9820
Affinity Capture-MS Homo sapiens
19 TRIM17  
Affinity Capture-MS Homo sapiens
20 CCT8L2  
Affinity Capture-MS Homo sapiens
21 NOTCH1 4851
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
22 UBXN6 80700
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CAMK4 is involved
PathwayEvidenceSource
Activation of NMDA receptors and postsynaptic events IEA Reactome
Activation of NMDA receptors and postsynaptic events TAS Reactome
Ca-dependent events IEA Reactome
Ca-dependent events TAS Reactome
Calmodulin induced events IEA Reactome
Calmodulin induced events TAS Reactome
CaM pathway IEA Reactome
CaM pathway TAS Reactome
CaMK IV-mediated phosphorylation of CREB IEA Reactome
CaMK IV-mediated phosphorylation of CREB TAS Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde IEA Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde TAS Reactome
DAG and IP3 signaling IEA Reactome
DAG and IP3 signaling TAS Reactome
Disease IEA Reactome
Disorders of Developmental Biology IEA Reactome
Disorders of Nervous System Development IEA Reactome
G alpha (i) signalling events IEA Reactome
G alpha (i) signalling events TAS Reactome
G-protein mediated events IEA Reactome
G-protein mediated events TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
GPCR downstream signalling IEA Reactome
GPCR downstream signalling TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Loss of function of MECP2 in Rett syndrome IEA Reactome
Loss of phosphorylation of MECP2 at T308 IEA Reactome
Mitochondrial biogenesis IEA Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission IEA Reactome
Neuronal System IEA Reactome
Neuronal System TAS Reactome
Neurotransmitter receptors and postsynaptic signal transmission IEA Reactome
Neurotransmitter receptors and postsynaptic signal transmission TAS Reactome
Opioid Signalling IEA Reactome
Opioid Signalling TAS Reactome
Organelle biogenesis and maintenance IEA Reactome
Pervasive developmental disorders IEA Reactome
PLC beta mediated events IEA Reactome
PLC beta mediated events TAS Reactome
Post NMDA receptor activation events IEA Reactome
Post NMDA receptor activation events TAS Reactome
Regulation of MECP2 expression and activity IEA Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by GPCR IEA Reactome
Signaling by GPCR TAS Reactome
Transcriptional activation of mitochondrial biogenesis IEA Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transmission across Chemical Synapses IEA Reactome
Transmission across Chemical Synapses TAS Reactome





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