Gene description for CAMP
Gene name cathelicidin antimicrobial peptide
Gene symbol CAMP
Other names/aliases CAP-18
CAP18
CRAMP
FALL-39
FALL39
HSD26
LL37
Species Homo sapiens
 Database cross references - CAMP
ExoCarta ExoCarta_820
Vesiclepedia VP_820
Entrez Gene 820
HGNC 1472
MIM 600474
UniProt P49913  
 CAMP identified in sEVs derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Urine 19056867    
 Gene ontology annotations for CAMP
Molecular Function
    lipopolysaccharide binding GO:0001530 IBA
    protein binding GO:0005515 IPI
Biological Process
    response to yeast GO:0001878 IDA
    innate immune response in mucosa GO:0002227 IDA
    chronic inflammatory response GO:0002544 IMP
    positive regulation of cell population proliferation GO:0008284 IEA
    antibacterial humoral response GO:0019731 IDA
    antifungal humoral response GO:0019732 IDA
    cytolysis GO:0019835 EXP
    positive regulation of interleukin-8 production GO:0032757 IMP
    modulation of process of another organism GO:0035821 IDA
    neutrophil activation GO:0042119 IDA
    defense response to bacterium GO:0042742 IMP
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IDA
    innate immune response GO:0045087 IMP
    positive regulation of angiogenesis GO:0045766 IEA
    defense response to Gram-negative bacterium GO:0050829 IBA
    defense response to Gram-negative bacterium GO:0050829 IDA
    defense response to Gram-positive bacterium GO:0050830 IBA
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to Gram-positive bacterium GO:0050830 IMP
    cytolysis by host of symbiont cells GO:0051838 IDA
    killing by host of symbiont cells GO:0051873 IDA
    killing by host of symbiont cells GO:0051873 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IMP
    cellular response to lipopolysaccharide GO:0071222 IEA
    cellular response to peptidoglycan GO:0071224 IEA
    cellular response to interleukin-1 GO:0071347 IEA
    cellular response to interleukin-6 GO:0071354 IEA
    cellular response to tumor necrosis factor GO:0071356 IEA
    amyloid fibril formation GO:1990000 EXP
    amyloid fibril formation GO:1990000 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    specific granule lumen GO:0035580 TAS
    specific granule GO:0042581 IDA
    cell projection GO:0042995 IEA
    extracellular exosome GO:0070062 HDA
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified CAMP in sEVs
1
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CAMP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F10 2159
Protein-peptide Homo sapiens
2 USP36  
Affinity Capture-MS Homo sapiens
3 MAPK8 5599
Two-hybrid Homo sapiens
4 KLK10 5655
Affinity Capture-MS Homo sapiens
5 F2 2147
Protein-peptide Homo sapiens
6 IGF1R 3480
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CAMP is involved
PathwayEvidenceSource
Antimicrobial peptides TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Neutrophil degranulation TAS Reactome





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