Gene description for AXIN2
Gene name	axin 2
Gene symbol	AXIN2
Other names/aliases	AXIL ODCRCS
Species	Homo sapiens
Database cross references - AXIN2
ExoCarta	ExoCarta_8313
Vesiclepedia	VP_8313
Entrez Gene	8313
HGNC	904
MIM	604025
UniProt	Q9Y2T1
AXIN2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Hepatocytes	26054723

Gene ontology annotations for AXIN2

Molecular Function     protein binding GO:0005515 IPI     beta-catenin binding GO:0008013 IBA     beta-catenin binding GO:0008013 NAS     enzyme binding GO:0019899 IPI     protein kinase binding GO:0019901 IBA     ubiquitin protein ligase binding GO:0031625 IBA     ubiquitin protein ligase binding GO:0031625 IPI     molecular adaptor activity GO:0060090 IBA     I-SMAD binding GO:0070411 IBA Biological Process     osteoblast differentiation GO:0001649 IEA     somitogenesis GO:0001756 IEA     positive regulation of protein phosphorylation GO:0001934 IMP     intramembranous ossification GO:0001957 IEA     secondary heart field specification GO:0003139 IEA     aortic valve morphogenesis GO:0003180 ISS     mitral valve morphogenesis GO:0003183 ISS     chondrocyte differentiation involved in endochondral bone morphogenesis GO:0003413 IEA     protein localization GO:0008104 IDA     dorsal/ventral axis specification GO:0009950 IEA     positive regulation of epithelial to mesenchymal transition GO:0010718 IMP     bone mineralization GO:0030282 IEA     regulation of mismatch repair GO:0032423 IMP     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IBA     osteoblast proliferation GO:0033687 IEA     negative regulation of osteoblast proliferation GO:0033689 IEA     odontogenesis GO:0042476 IMP     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 NAS     maintenance of DNA repeat elements GO:0043570 IMP     positive regulation of fat cell differentiation GO:0045600 IEA     negative regulation of osteoblast differentiation GO:0045668 IEA     mRNA stabilization GO:0048255 IMP     cell development GO:0048468 IBA     canonical Wnt signaling pathway GO:0060070 IMP     regulation of chondrocyte development GO:0061181 IEA     regulation of centromeric sister chromatid cohesion GO:0070602 IBA     regulation of centromeric sister chromatid cohesion GO:0070602 IMP     cellular response to dexamethasone stimulus GO:0071549 IEA     stem cell proliferation GO:0072089 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 IBA     negative regulation of canonical Wnt signaling pathway GO:0090090 IDA     negative regulation of canonical Wnt signaling pathway GO:0090090 IMP     negative regulation of canonical Wnt signaling pathway GO:0090090 ISS     regulation of extracellular matrix organization GO:1903053 ISS Subcellular Localization     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     centrosome GO:0005813 IDA     cytosol GO:0005829 TAS     plasma membrane GO:0005886 IBA     beta-catenin destruction complex GO:0030877 IBA     beta-catenin destruction complex GO:0030877 NAS