Gene description for SCRT1
Gene name scratch family zinc finger 1
Gene symbol SCRT1
Other names/aliases SCRT
ZNF898
Species Homo sapiens
 Database cross references - SCRT1
ExoCarta ExoCarta_83482
Vesiclepedia VP_83482
Entrez Gene 83482
HGNC 15950
MIM 605858
UniProt Q9BWW7  
 SCRT1 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SCRT1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IDA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    DNA-binding transcription factor activity GO:0003700 NAS
    sequence-specific DNA binding GO:0043565 IDA
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of DNA-templated transcription GO:0006355 IBA
    regulation of DNA-templated transcription GO:0006355 TAS
    regulation of neuron migration GO:2001222 IEA
Subcellular Localization
    nuclear body GO:0016604 IDA
 Experiment description of studies that identified SCRT1 in sEVs
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SCRT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NES 10763
Affinity Capture-MS Homo sapiens
2 VRK3 51231
Affinity Capture-MS Homo sapiens
3 SORL1 6653
Affinity Capture-MS Homo sapiens
4 KLHDC10 23008
Affinity Capture-MS Homo sapiens
5 PRMT9  
Affinity Capture-MS Homo sapiens
6 WWP1 11059
Affinity Capture-MS Homo sapiens
7 IMPDH1 3614
Affinity Capture-MS Homo sapiens
8 ZNF579  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SCRT1 is involved
No pathways found





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