Gene description for Rtn4
Gene name	reticulon 4
Gene symbol	Rtn4
Other names/aliases	NI-250 Nogo Nogo-A Vp20 r rat N rat NogoA
Species	Rattus norvegicus
Database cross references - Rtn4
ExoCarta	ExoCarta_83765
Vesiclepedia	VP_83765
Entrez Gene	83765
UniProt	Q9JK11
Rtn4 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041

Gene ontology annotations for Rtn4

Molecular Function     protein binding GO:0005515 IPI     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     protein homodimerization activity GO:0042803 ISO     protein-containing complex binding GO:0044877 IDA     cadherin binding GO:0045296 ISO     metal ion binding GO:0046872 ISO Biological Process     blastocyst formation GO:0001825 IEA     blastocyst formation GO:0001825 ISO     leukocyte migration involved in inflammatory response GO:0002523 ISO     leukocyte migration involved in inflammatory response GO:0002523 ISS     endoplasmic reticulum organization GO:0007029 ISO     nervous system development GO:0007399 ISO     axonal fasciculation GO:0007413 IDA     axonal fasciculation GO:0007413 IEA     axonal fasciculation GO:0007413 ISO     brain development GO:0007420 IBA     positive regulation of epithelial cell migration GO:0010634 IEA     positive regulation of epithelial cell migration GO:0010634 ISO     negative regulation of neuron projection development GO:0010977 IDA     response to activity GO:0014823 IEP     olfactory nerve development GO:0021553 IEP     cerebral cortex radial glia-guided migration GO:0021801 IEA     cerebral cortex radial glia-guided migration GO:0021801 ISO     cerebral cortex radial glia-guided migration GO:0021801 ISS     central nervous system vasculogenesis GO:0022009 ISO     central nervous system vasculogenesis GO:0022009 ISS     neuron differentiation GO:0030182 IBA     negative regulation of cell growth GO:0030308 ISO     regulation of cell migration GO:0030334 ISO     negative regulation of axon extension GO:0030517 IDA     negative regulation of axon extension GO:0030517 IEA     negative regulation of axon extension GO:0030517 ISO     negative regulation of axon extension GO:0030517 ISS     positive regulation of mammary gland epithelial cell proliferation GO:0033601 IEA     positive regulation of mammary gland epithelial cell proliferation GO:0033601 ISO     positive regulation of dopamine secretion GO:0033603 IMP     positive regulation of toll-like receptor 9 signaling pathway GO:0034165 IEA     positive regulation of toll-like receptor 9 signaling pathway GO:0034165 ISO     positive regulation of toll-like receptor 9 signaling pathway GO:0034165 ISS     positive regulation of Rac protein signal transduction GO:0035022 ISO     positive regulation of Rac protein signal transduction GO:0035022 ISS     cell migration involved in vasculogenesis GO:0035441 ISO     cell migration involved in vasculogenesis GO:0035441 ISS     negative regulation of neuron differentiation GO:0045665 IDA     positive regulation of glial cell differentiation GO:0045687 IDA     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of angiogenesis GO:0045766 ISS     oligodendrocyte differentiation GO:0048709 IEP     negative regulation of axonogenesis GO:0050771 IDA     negative regulation of axonogenesis GO:0050771 IMP     modulation of chemical synaptic transmission GO:0050804 IEA     modulation of chemical synaptic transmission GO:0050804 ISO     protein stabilization GO:0050821 IEA     protein stabilization GO:0050821 ISO     nuclear pore complex assembly GO:0051292 IEA     nuclear pore complex assembly GO:0051292 ISO     nuclear pore complex assembly GO:0051292 ISS     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     regulation of nervous system development GO:0051960 ISO     cardiac epithelial to mesenchymal transition GO:0060317 IEA     cardiac epithelial to mesenchymal transition GO:0060317 ISO     positive regulation of macrophage cytokine production GO:0060907 ISO     positive regulation of macrophage cytokine production GO:0060907 ISS     protein localization to lysosome GO:0061462 IEA     protein localization to lysosome GO:0061462 ISO     protein localization to lysosome GO:0061462 ISS     negative regulation of neuron projection regeneration GO:0070571 IMP     cellular response to hypoxia GO:0071456 ISO     cellular response to hypoxia GO:0071456 ISS     endoplasmic reticulum tubular network organization GO:0071786 ISO     endoplasmic reticulum tubular network organization GO:0071786 ISS     endoplasmic reticulum tubular network formation GO:0071787 IBA     endoplasmic reticulum tubular network formation GO:0071787 IEA     endoplasmic reticulum tubular network formation GO:0071787 ISO     endoplasmic reticulum tubular network formation GO:0071787 ISS     intracellular sphingolipid homeostasis GO:0090156 IEA     intracellular sphingolipid homeostasis GO:0090156 ISO     cell adhesion involved in sprouting angiogenesis GO:0120078 ISO     cell adhesion involved in sprouting angiogenesis GO:0120078 ISS     regulation of postsynapse assembly GO:0150052 IEA     regulation of postsynapse assembly GO:0150052 ISO     negative regulation of amyloid-beta formation GO:1902430 IEA     negative regulation of amyloid-beta formation GO:1902430 ISO     negative regulation of amyloid-beta formation GO:1902430 ISS     positive regulation of neutrophil migration GO:1902624 ISO     positive regulation of neutrophil migration GO:1902624 ISS     positive regulation of macrophage migration GO:1905523 ISO     positive regulation of macrophage migration GO:1905523 ISS     positive regulation of protein localization to endoplasmic reticulum GO:1905552 IEA     positive regulation of protein localization to endoplasmic reticulum GO:1905552 ISO     positive regulation of ERBB3 signaling pathway GO:1905580 IEA     positive regulation of ERBB3 signaling pathway GO:1905580 ISO     positive regulation of artery morphogenesis GO:1905653 ISO     positive regulation of artery morphogenesis GO:1905653 ISS     endoplasmic reticulum tubular network membrane organization GO:1990809 IEA     endoplasmic reticulum tubular network membrane organization GO:1990809 ISO     endoplasmic reticulum tubular network membrane organization GO:1990809 ISS     regulation of branching morphogenesis of a nerve GO:2000172 IDA     regulation of branching morphogenesis of a nerve GO:2000172 IEA     regulation of branching morphogenesis of a nerve GO:2000172 ISO     positive regulation of hepatocyte proliferation GO:2000347 ISO     positive regulation of hepatocyte proliferation GO:2000347 ISS     negative regulation of vasculogenesis GO:2001213 ISO     negative regulation of vasculogenesis GO:2001213 ISS Subcellular Localization     nuclear envelope GO:0005635 IEA     nuclear envelope GO:0005635 ISO     nuclear envelope GO:0005635 ISS     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum membrane GO:0005789 IBA     endoplasmic reticulum membrane GO:0005789 IDA     endoplasmic reticulum membrane GO:0005789 IEA     endoplasmic reticulum membrane GO:0005789 ISO     plasma membrane GO:0005886 ISO     postsynaptic density GO:0014069 IBA     postsynaptic density GO:0014069 IEA     postsynaptic density GO:0014069 ISO     cell junction GO:0030054 ISO     cell junction GO:0030054 ISS     protein-containing complex GO:0032991 IDA     cell projection GO:0042995 IEA     cell projection GO:0042995 ISO     neuron projection GO:0043005 IBA     neuronal cell body GO:0043025 IDA     neuronal cell body GO:0043025 IEA     synapse GO:0045202 ISO     synapse GO:0045202 ISS     anchoring junction GO:0070161 IEA     endoplasmic reticulum tubular network GO:0071782 ISO     postsynapse GO:0098794 IDA     postsynapse GO:0098794 ISO     endoplasmic reticulum tubular network membrane GO:0098826 IEA     endoplasmic reticulum tubular network membrane GO:0098826 ISO     endoplasmic reticulum tubular network membrane GO:0098826 ISS     postsynaptic density membrane GO:0098839 IDA     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO