Gene description for SNX25
Gene name sorting nexin 25
Gene symbol SNX25
Other names/aliases MSTP043
SBBI31
Species Homo sapiens
 Database cross references - SNX25
ExoCarta ExoCarta_83891
Vesiclepedia VP_83891
Entrez Gene 83891
HGNC 21883
UniProt Q9H3E2  
 SNX25 identified in sEVs derived from the following tissue/cell type
Malignant pleural effusions 14975938    
Neuroblastoma cells 25944692    
 Gene ontology annotations for SNX25
Molecular Function
    phosphatidylinositol binding GO:0035091 IBA
Biological Process
    protein transport GO:0015031 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP
    receptor catabolic process GO:0032801 IMP
Subcellular Localization
    endosome GO:0005768 IBA
    endosome membrane GO:0010008 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified SNX25 in sEVs
1
Experiment ID 51
MISEV standards
EM
Biophysical techniques
HSP90|MHCII
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors "Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN"
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Breast cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
2
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SNX25
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZDHHC12  
Affinity Capture-MS Homo sapiens
2 ATP6V0D1 9114
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 COA3 28958
Affinity Capture-MS Homo sapiens
4 GJA8  
Affinity Capture-MS Homo sapiens
5 TSPAN5 10098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 GJA3  
Affinity Capture-MS Homo sapiens
7 TSPAN15 23555
Affinity Capture-MS Homo sapiens
8 NDUFC2 4718
Affinity Capture-MS Homo sapiens
9 B4GAT1 11041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 VAPB 9217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 HSP90B1 7184
Cross-Linking-MS (XL-MS) Homo sapiens
12 GBA 2629
Affinity Capture-MS Homo sapiens
13 APH1A 51107
Affinity Capture-MS Homo sapiens
14 TTYH1  
Affinity Capture-MS Homo sapiens
15 SIX5  
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which SNX25 is involved
No pathways found





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