Gene description for Col3a1
Gene name collagen, type III, alpha 1
Gene symbol Col3a1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Col3a1
ExoCarta ExoCarta_84032
Vesiclepedia VP_84032
Entrez Gene 84032
UniProt P13941  
 Col3a1 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Col3a1
Molecular Function
    protease binding GO:0002020 ISO
    integrin binding GO:0005178 ISO
    extracellular matrix structural constituent GO:0005201 ISO
    extracellular matrix structural constituent conferring tensile strength GO:0030020 IBA
    SMAD binding GO:0046332 ISO
    metal ion binding GO:0046872 IEA
    platelet-derived growth factor binding GO:0048407 ISO
Biological Process
    skeletal system development GO:0001501 IEP
    blood vessel development GO:0001568 ISO
    in utero embryonic development GO:0001701 ISO
    neuron migration GO:0001764 ISO
    tissue homeostasis GO:0001894 ISO
    chondrocyte differentiation GO:0002062 ISO
    cell-matrix adhesion GO:0007160 ISO
    transforming growth factor beta receptor signaling pathway GO:0007179 ISO
    integrin-mediated signaling pathway GO:0007229 ISO
    heart development GO:0007507 ISO
    response to radiation GO:0009314 ISO
    response to mechanical stimulus GO:0009612 IEP
    gene expression GO:0010467 ISO
    peptide cross-linking GO:0018149 ISO
    layer formation in cerebral cortex GO:0021819 ISO
    cerebral cortex development GO:0021987 ISO
    cerebral cortex development GO:0021987 ISS
    extracellular matrix organization GO:0030198 IBA
    extracellular matrix organization GO:0030198 ISO
    collagen fibril organization GO:0030199 ISO
    collagen fibril organization GO:0030199 ISO
    lung development GO:0030324 ISO
    transforming growth factor beta1 production GO:0032905 ISO
    response to cytokine GO:0034097 ISO
    positive regulation of Rho protein signal transduction GO:0035025 ISO
    positive regulation of Rho protein signal transduction GO:0035025 ISS
    multicellular organism growth GO:0035264 ISO
    aorta development GO:0035904 ISO
    limb joint morphogenesis GO:0036022 ISO
    wound healing GO:0042060 ISO
    skin development GO:0043588 ISO
    fibroblast proliferation GO:0048144 ISO
    elastic fiber assembly GO:0048251 ISO
    digestive tract development GO:0048565 ISO
    digestive tract development GO:0048565 ISO
    negative regulation of immune response GO:0050777 ISO
    cartilage development GO:0051216 ISO
    endochondral bone morphogenesis GO:0060350 ISO
    aorta smooth muscle tissue morphogenesis GO:0060414 ISO
    cellular response to amino acid stimulus GO:0071230 ISO
    basement membrane organization GO:0071711 ISO
    supramolecular fiber organization GO:0097435 ISO
    response to angiotensin GO:1990776 ISO
    negative regulation of neuron migration GO:2001223 ISO
    negative regulation of neuron migration GO:2001223 ISS
Subcellular Localization
    collagen trimer GO:0005581 ISO
    collagen type III trimer GO:0005586 ISO
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    extracellular matrix GO:0031012 ISO
    collagen-containing extracellular matrix GO:0062023 IBA
    collagen-containing extracellular matrix GO:0062023 IDA
    collagen-containing extracellular matrix GO:0062023 ISO
 Experiment description of studies that identified Col3a1 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Col3a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here