Gene description for FBN3
Gene name fibrillin 3
Gene symbol FBN3
Other names/aliases -
Species Homo sapiens
 Database cross references - FBN3
ExoCarta ExoCarta_84467
Vesiclepedia VP_84467
Entrez Gene 84467
HGNC 18794
MIM 608529
UniProt Q75N90  
 FBN3 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FBN3
Molecular Function
    extracellular matrix structural constituent GO:0005201 IBA
    calcium ion binding GO:0005509 IEA
Biological Process
    anatomical structure morphogenesis GO:0009653 IBA
Subcellular Localization
    microfibril GO:0001527 IEA
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 IBA
 Experiment description of studies that identified FBN3 in sEVs
1
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FBN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TSC22D1 8848
Two-hybrid Homo sapiens
2 GADD45A  
Two-hybrid Homo sapiens
3 NUDT21 11051
Two-hybrid Homo sapiens
4 DAZAP2  
Two-hybrid Homo sapiens
5 PIK3R3 8503
Two-hybrid Homo sapiens
6 ANXA7 310
Two-hybrid Homo sapiens
7 C11orf58  
Two-hybrid Homo sapiens
8 BID  
Two-hybrid Homo sapiens
9 RPN2 6185
Two-hybrid Homo sapiens
10 TK1 7083
Two-hybrid Homo sapiens
11 CDKN1A  
Two-hybrid Homo sapiens
12 GSK3B 2932
Two-hybrid Homo sapiens
13 RPS6KA6 27330
Two-hybrid Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here