Gene description for INSM2
Gene name insulinoma-associated 2
Gene symbol INSM2
Other names/aliases IA-6
IA6
mlt1
Species Homo sapiens
 Database cross references - INSM2
ExoCarta ExoCarta_84684
Vesiclepedia VP_84684
Entrez Gene 84684
HGNC 17539
MIM 614027
UniProt Q96T92  
 INSM2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for INSM2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    regulation of cell cycle process GO:0010564 IBA
    neuron differentiation GO:0030182 IBA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IEA
    transcription repressor complex GO:0017053 IBA
 Experiment description of studies that identified INSM2 in sEVs
1
Experiment ID 235
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for INSM2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZSCAN1  
Two-hybrid Homo sapiens
2 RHOU 58480
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which INSM2 is involved
No pathways found





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