Gene description for SLC22A16
Gene name solute carrier family 22 (organic cation/carnitine transporter), member 16
Gene symbol SLC22A16
Other names/aliases CT2
FLIPT2
OAT6
OCT6
OKB1
dJ261K5.1
Species Homo sapiens
 Database cross references - SLC22A16
ExoCarta ExoCarta_85413
Vesiclepedia VP_85413
Entrez Gene 85413
HGNC 20302
MIM 608276
UniProt Q86VW1  
 SLC22A16 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for SLC22A16
Molecular Function
    amine transmembrane transporter activity GO:0005275 IDA
    organic cation transmembrane transporter activity GO:0015101 IBA
    organic cation transmembrane transporter activity GO:0015101 IDA
    carnitine transmembrane transporter activity GO:0015226 IDA
    carnitine transmembrane transporter activity GO:0015226 TAS
    spermidine transmembrane transporter activity GO:0015606 IDA
Biological Process
    monoatomic ion transport GO:0006811 IEA
    spermatogenesis GO:0007283 IEA
    single fertilization GO:0007338 IMP
    organic cation transport GO:0015695 IBA
    organic cation transport GO:0015695 IDA
    organic cation transport GO:0015695 IDA
    amine transport GO:0015837 IEA
    carnitine transport GO:0015879 IDA
    carnitine transport GO:0015879 IDA
    cell differentiation GO:0030154 IEA
    flagellated sperm motility GO:0030317 IMP
    acid secretion GO:0046717 IDA
    carnitine transmembrane transport GO:1902603 IDA
    spermidine transmembrane transport GO:1903711 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified SLC22A16 in sEVs
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC22A16
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLVCR1 28982
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SPPL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GJC1 10052
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SLC29A1 2030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 SYNGR2 9144
Affinity Capture-MS Homo sapiens
6 TMEM164  
Affinity Capture-MS Homo sapiens
7 TSPAN15 23555
Affinity Capture-MS Homo sapiens
8 ATL3 25923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FOXP1 27086
Protein-RNA Homo sapiens
10 NR3C1 2908
Proximity Label-MS Homo sapiens
11 PXMP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 SLC26A2 1836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 APBA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TMEM115 11070
Affinity Capture-MS Homo sapiens
15 MFSD8 256471
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 LPCAT3 10162
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RAB21 23011
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SGPP1 81537
Affinity Capture-MS Homo sapiens
19 SERINC1 57515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 GBP5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ORAI1 84876
Affinity Capture-MS Homo sapiens
23 FNDC3A 22862
Affinity Capture-MS Homo sapiens
24 MTX3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 TMEM56  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 AGPAT2  
Affinity Capture-MS Homo sapiens
27 TMEM104 54868
Affinity Capture-MS Homo sapiens
28 ADIPOR1 51094
Affinity Capture-MS Homo sapiens
29 SLC25A30 253512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CHCHD6 84303
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CCRN4L  
Affinity Capture-MS Homo sapiens
32 SLC25A46 91137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 ACSM1 116285
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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