Gene description for ALDH1A2
Gene name aldehyde dehydrogenase 1 family, member A2
Gene symbol ALDH1A2
Other names/aliases RALDH(II)
RALDH2
RALDH2-T
Species Homo sapiens
 Database cross references - ALDH1A2
ExoCarta ExoCarta_8854
Vesiclepedia VP_8854
Entrez Gene 8854
HGNC 15472
MIM 603687
UniProt O94788  
 ALDH1A2 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ALDH1A2
Molecular Function
    retinal dehydrogenase activity GO:0001758 IDA
    retinal dehydrogenase activity GO:0001758 ISS
    3-chloroallyl aldehyde dehydrogenase activity GO:0004028 ISS
    aldehyde dehydrogenase (NAD+) activity GO:0004029 IBA
    retinal binding GO:0016918 ISS
Biological Process
    blood vessel development GO:0001568 IEA
    kidney development GO:0001822 IEA
    liver development GO:0001889 IEA
    retinoic acid biosynthetic process GO:0002138 IDA
    retinoic acid biosynthetic process GO:0002138 IMP
    heart morphogenesis GO:0003007 IEA
    vitamin A metabolic process GO:0006776 NAS
    midgut development GO:0007494 IEA
    cell population proliferation GO:0008283 IEA
    positive regulation of cell population proliferation GO:0008284 IEA
    negative regulation of cell population proliferation GO:0008285 IDA
    determination of bilateral symmetry GO:0009855 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    proximal/distal pattern formation GO:0009954 IEA
    positive regulation of gene expression GO:0010628 IEA
    neural crest cell development GO:0014032 IEA
    morphogenesis of embryonic epithelium GO:0016331 IEA
    neural tube development GO:0021915 IMP
    pituitary gland development GO:0021983 IEA
    neuron differentiation GO:0030182 IEA
    lung development GO:0030324 IEA
    hindbrain development GO:0030902 IEA
    pancreas development GO:0031016 IEA
    embryonic camera-type eye development GO:0031076 IEA
    response to estradiol GO:0032355 IEA
    response to retinoic acid GO:0032526 IMP
    response to vitamin A GO:0033189 IEA
    response to cytokine GO:0034097 IDA
    embryonic forelimb morphogenesis GO:0035115 IEA
    ureter maturation GO:0035799 IEA
    retinol metabolic process GO:0042572 IEA
    retinoic acid metabolic process GO:0042573 IMP
    retinoic acid metabolic process GO:0042573 ISS
    retinal metabolic process GO:0042574 IEA
    9-cis-retinoic acid biosynthetic process GO:0042904 IEA
    positive regulation of apoptotic process GO:0043065 IEA
    retinoic acid receptor signaling pathway GO:0048384 IEA
    embryonic digestive tract development GO:0048566 IEA
    cardiac muscle tissue development GO:0048738 IEA
    protein homotetramerization GO:0051289 IDA
    face development GO:0060324 IEA
    cellular response to retinoic acid GO:0071300 IEA
    regulation of vascular endothelial cell proliferation GO:1905562 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified ALDH1A2 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ALDH1A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KPTN  
Affinity Capture-MS Homo sapiens
2 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
3 AKTIP  
Affinity Capture-MS Homo sapiens
4 HOOK1  
Proximity Label-MS Homo sapiens
5 HTRA2 27429
Protein-peptide Homo sapiens
6 MARCKS 4082
Proximity Label-MS Homo sapiens
7 CA4 762
Affinity Capture-MS Homo sapiens
8 ANKRD33  
Affinity Capture-MS Homo sapiens
9 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ERLEC1 27248
Affinity Capture-MS Homo sapiens
11 UBE3A 7337
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
12 PRPH 5630
Proximity Label-MS Homo sapiens
13 NANS 54187
Affinity Capture-MS Homo sapiens
14 ZNF69  
Affinity Capture-MS Homo sapiens
15 BOC  
Affinity Capture-MS Homo sapiens
16 GAL  
Affinity Capture-MS Homo sapiens
17 OR3A1  
Affinity Capture-MS Homo sapiens
18 METTL6  
Affinity Capture-MS Homo sapiens
19 SH3BGRL3 83442
Affinity Capture-MS Homo sapiens
20 ANAPC2 29882
Proximity Label-MS Homo sapiens
21 CHMP6 79643
Affinity Capture-MS Homo sapiens
22 IDS  
Affinity Capture-MS Homo sapiens
23 ALDH1A1 216
Affinity Capture-MS Homo sapiens
24 RPA3 6119
Proximity Label-MS Homo sapiens
25 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
26 OGT 8473
Reconstituted Complex Homo sapiens
27 CLTA 1211
Proximity Label-MS Homo sapiens
28 MPZL1 9019
Affinity Capture-MS Homo sapiens
29 BICD2 23299
Proximity Label-MS Homo sapiens
30 CCDC53 51019
Affinity Capture-MS Homo sapiens
31 SFXN2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ALDH1A2 is involved
PathwayEvidenceSource
RA biosynthesis pathway TAS Reactome
Signal Transduction TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Retinoic Acid TAS Reactome





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