Gene description for IL1RL1
Gene name interleukin 1 receptor-like 1
Gene symbol IL1RL1
Other names/aliases DER4
FIT-1
IL33R
ST2
ST2L
ST2V
T1
Species Homo sapiens
 Database cross references - IL1RL1
ExoCarta ExoCarta_9173
Vesiclepedia VP_9173
Entrez Gene 9173
HGNC 5998
MIM 601203
UniProt Q01638  
 IL1RL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IL1RL1
Molecular Function
    interleukin-33 binding GO:0002113 IBA
    interleukin-33 receptor activity GO:0002114 IDA
    NAD+ nucleosidase activity GO:0003953 IEA
    cytokine receptor activity GO:0004896 TAS
    interleukin-1 receptor activity GO:0004908 IEA
    protein binding GO:0005515 IPI
    NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 IEA
Biological Process
    negative regulation of T-helper 1 type immune response GO:0002826 IEA
    inflammatory response GO:0006954 ISS
    immune response GO:0006955 NAS
    signal transduction GO:0007165 TAS
    macrophage differentiation GO:0030225 ISS
    negative regulation of type II interferon production GO:0032689 IEA
    positive regulation of chemokine production GO:0032722 IEA
    positive regulation of interleukin-5 production GO:0032754 IEA
    interleukin-33-mediated signaling pathway GO:0038172 IBA
    interleukin-33-mediated signaling pathway GO:0038172 IDA
    positive regulation of macrophage activation GO:0043032 IEA
    positive regulation of inflammatory response GO:0050729 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IC
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 IDA
    external side of plasma membrane GO:0009897 IEA
    cell surface GO:0009986 IBA
 Experiment description of studies that identified IL1RL1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IL1RL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 MYD88 4615
Affinity Capture-Western Homo sapiens
3 GPR152  
Two-hybrid Homo sapiens
4 IRAK4 51135
Affinity Capture-Western Homo sapiens
5 ASGR2  
Two-hybrid Homo sapiens
6 MCFD2 90411
Two-hybrid Homo sapiens
7 TRAF6 7189
Affinity Capture-Western Homo sapiens
8 HRAS 3265
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 GPR42  
Two-hybrid Homo sapiens
10 SIGLEC12  
Two-hybrid Homo sapiens
11 IRAK1  
Affinity Capture-Western Homo sapiens
12 TSPAN18 90139
Two-hybrid Homo sapiens
13 CLEC12B  
Two-hybrid Homo sapiens
14 CLEC7A  
Two-hybrid Homo sapiens
15 YIPF6 286451
Two-hybrid Homo sapiens
16 SLC38A1 81539
Two-hybrid Homo sapiens
17 TMED1 11018
Reconstituted Complex Homo sapiens
18 IL33  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
19 CREB3L1  
Two-hybrid Homo sapiens
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