Gene description for MFHAS1
Gene name malignant fibrous histiocytoma amplified sequence 1
Gene symbol MFHAS1
Other names/aliases LRRC65
MASL1
Species Homo sapiens
 Database cross references - MFHAS1
ExoCarta ExoCarta_9258
Vesiclepedia VP_9258
Entrez Gene 9258
HGNC 16982
MIM 605352
UniProt Q9Y4C4  
 MFHAS1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MFHAS1
Molecular Function
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    protein phosphatase 2A binding GO:0051721 IDA
Biological Process
    inflammatory response GO:0006954 IBA
    inflammatory response GO:0006954 IMP
    erythrocyte differentiation GO:0030218 IMP
    regulation of toll-like receptor signaling pathway GO:0034121 IEA
    negative regulation of toll-like receptor 2 signaling pathway GO:0034136 IMP
    positive regulation of toll-like receptor 2 signaling pathway GO:0034137 IMP
    negative regulation of toll-like receptor 4 signaling pathway GO:0034144 IMP
    intracellular signal transduction GO:0035556 IBA
    intracellular signal transduction GO:0035556 IMP
    regulation of macrophage activation GO:0043030 IMP
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IMP
    positive regulation of JNK cascade GO:0046330 IMP
    negative regulation of inflammatory response GO:0050728 IMP
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    negative regulation of protein localization to nucleus GO:1900181 IMP
    positive regulation of p38MAPK cascade GO:1900745 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    lysosome GO:0005764 IDA
    cytoskeleton GO:0005856 IDA
 Experiment description of studies that identified MFHAS1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MFHAS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CEP164  
Affinity Capture-MS Homo sapiens
2 ZNF703  
Affinity Capture-MS Homo sapiens
3 KRAS 3845
Synthetic Growth Defect Homo sapiens
4 CCDC22 28952
Affinity Capture-MS Homo sapiens
5 ABHD16B  
Affinity Capture-MS Homo sapiens
6 KIF3A 11127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CAMSAP1 157922
Affinity Capture-MS Homo sapiens
8 TMEM132A 54972
Affinity Capture-MS Homo sapiens
9 CENPO  
Affinity Capture-MS Homo sapiens
10 PGRMC2 10424
Affinity Capture-MS Homo sapiens
11 RBM12 10137
Affinity Capture-MS Homo sapiens
12 DNAL1  
Affinity Capture-MS Homo sapiens
13 KIFAP3 22920
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MFHAS1 is involved
No pathways found





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