Gene description for TJAP1
Gene name tight junction associated protein 1 (peripheral)
Gene symbol TJAP1
Other names/aliases PILT
TJP4
Species Homo sapiens
 Database cross references - TJAP1
ExoCarta ExoCarta_93643
Vesiclepedia VP_93643
Entrez Gene 93643
HGNC 17949
MIM 612658
UniProt Q5JTD0  
 TJAP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TJAP1
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    Golgi organization GO:0007030 IBA
Subcellular Localization
    endosome GO:0005768 IEA
    Golgi apparatus GO:0005794 IDA
    trans-Golgi network GO:0005802 IBA
    plasma membrane GO:0005886 IEA
    bicellular tight junction GO:0005923 IEA
 Experiment description of studies that identified TJAP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TJAP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MIS12  
Affinity Capture-MS Homo sapiens
2 ZWINT  
Affinity Capture-MS Homo sapiens
3 EBAG9 9166
Proximity Label-MS Homo sapiens
4 LAMTOR1 55004
Proximity Label-MS Homo sapiens
5 METTL7A 25840
Proximity Label-MS Homo sapiens
6 LAMP3  
Proximity Label-MS Homo sapiens
7 XPO1 7514
Affinity Capture-MS Homo sapiens
8 SYCE1  
Affinity Capture-MS Homo sapiens
9 APBA2 321
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 GOLGA6L9  
Two-hybrid Homo sapiens
11 ATG9A 79065
Proximity Label-MS Homo sapiens
12 DLG1 1739
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
13 KRT75 9119
Two-hybrid Homo sapiens
14 HSD3B7 80270
Proximity Label-MS Homo sapiens
15 Klc4  
Affinity Capture-MS Mus musculus
16 APBA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 FHL3 2275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LAMP2 3920
Proximity Label-MS Homo sapiens
19 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
20 ARF6 382
Proximity Label-MS Homo sapiens
21 GJA1 2697
Proximity Label-MS Homo sapiens
22 ELOVL5 60481
Proximity Label-MS Homo sapiens
23 TRIM54  
Two-hybrid Homo sapiens
24 APEX1 328
Affinity Capture-RNA Homo sapiens
25 Cep250  
Affinity Capture-MS Mus musculus
26 B3GAT1  
Proximity Label-MS Homo sapiens
27 RAB2A 5862
Proximity Label-MS Homo sapiens
28 TPM3P9  
Affinity Capture-MS Homo sapiens
29 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 GOLGA1  
Proximity Label-MS Homo sapiens
31 Tbc1d9b  
Affinity Capture-MS Mus musculus
32 CHST15 51363
Affinity Capture-MS Homo sapiens
33 MEOX2  
Two-hybrid Homo sapiens
34 CORO1A 11151
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 SF3B3 23450
Co-fractionation Homo sapiens
36 CTR9 9646
Affinity Capture-MS Homo sapiens
37 ACSL4 2182
Affinity Capture-MS Homo sapiens
38 VPS18 57617
Affinity Capture-MS Homo sapiens
39 APBA1  
Affinity Capture-MS Homo sapiens
40 PPME1 51400
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which TJAP1 is involved
No pathways found





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