Gene description for NRXN3
Gene name neurexin 3
Gene symbol NRXN3
Other names/aliases C14orf60
Species Homo sapiens
 Database cross references - NRXN3
ExoCarta ExoCarta_9369
Vesiclepedia VP_9369
Entrez Gene 9369
HGNC 8010
MIM 600567
UniProt Q9Y4C0   Q9HDB5  
 NRXN3 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NRXN3
Molecular Function
    transmembrane signaling receptor activity GO:0004888 NAS
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 TAS
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 TAS
    neuroligin family protein binding GO:0097109 TAS
Biological Process
    angiogenesis GO:0001525 ISS
    neuron cell-cell adhesion GO:0007158 TAS
    signal transduction GO:0007165 NAS
    axon guidance GO:0007411 TAS
    learning GO:0007612 IGI
    adult behavior GO:0030534 IGI
    social behavior GO:0035176 IGI
    vocalization behavior GO:0071625 IGI
Subcellular Localization
    plasma membrane GO:0005886 TAS
    presynaptic membrane GO:0042734 IEA
    presynaptic membrane GO:0042734 ISS
    cell projection GO:0042995 IEA
    trans-synaptic protein complex GO:0098820 ISS
 Experiment description of studies that identified NRXN3 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NRXN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HTR6  
Two-hybrid Homo sapiens
2 PIP5K1A 8394
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 CAMKV 79012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RANGAP1 5905
Cross-Linking-MS (XL-MS) Homo sapiens
5 CSTL1  
Affinity Capture-MS Homo sapiens
6 KRAS 3845
Synthetic Lethality Homo sapiens
7 PIP5K1P1  
Affinity Capture-MS Homo sapiens
8 FAM19A4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 LRRTM4  
Affinity Capture-MS Homo sapiens
10 MYC  
Affinity Capture-MS Homo sapiens
11 CBLN4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 MLLT4 4301
Two-hybrid Homo sapiens
13 HADHA 3030
Affinity Capture-MS Homo sapiens
14 GPR183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 LRRTM3  
Affinity Capture-MS Homo sapiens
16 FAM19A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TUB  
Affinity Capture-MS Homo sapiens
18 NLGN3  
Reconstituted Complex Homo sapiens
19 NLGN2 57555
Reconstituted Complex Homo sapiens
20 NLGN1  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which NRXN3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here