Gene description for CD40LG
Gene name	CD40 ligand
Gene symbol	CD40LG
Other names/aliases	CD154 CD40L HIGM1 IGM IMD3 T-BAM TNFSF5 TRAP gp39 hCD40L
Species	Homo sapiens
Database cross references - CD40LG
ExoCarta	ExoCarta_959
Vesiclepedia	VP_959
Entrez Gene	959
HGNC	11935
MIM	300386
UniProt	P29965
CD40LG identified in sEVs derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for CD40LG

Molecular Function     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IDA     tumor necrosis factor receptor binding GO:0005164 IEA     CD40 receptor binding GO:0005174 IMP     CD40 receptor binding GO:0005174 IPI     integrin binding GO:0005178 IMP     protein binding GO:0005515 IPI     protein serine/threonine kinase activator activity GO:0043539 IDA Biological Process     regulation of immunoglobulin production GO:0002637 IEA     inflammatory response GO:0006954 IDA     leukocyte cell-cell adhesion GO:0007159 NAS     cell surface receptor signaling pathway GO:0007166 IBA     integrin-mediated signaling pathway GO:0007229 IMP     CD40 signaling pathway GO:0023035 IDA     CD40 signaling pathway GO:0023035 IMP     platelet activation GO:0030168 IDA     B cell differentiation GO:0030183 IEA     T cell costimulation GO:0031295 TAS     positive regulation of interleukin-10 production GO:0032733 IDA     positive regulation of interleukin-12 production GO:0032735 IDA     positive regulation of interleukin-4 production GO:0032753 IDA     B cell proliferation GO:0042100 IDA     positive regulation of T cell proliferation GO:0042102 IDA     negative regulation of apoptotic process GO:0043066 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA     isotype switching GO:0045190 ISS     positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA     positive regulation of endothelial cell apoptotic process GO:2000353 IDA     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IBA Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     Golgi apparatus GO:0005794 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 IEA     cell surface GO:0009986 IDA     membrane GO:0016020 NAS