Gene description for ADAMTSL2
Gene name ADAMTS-like 2
Gene symbol ADAMTSL2
Other names/aliases GPHYSD1
Species Homo sapiens
 Database cross references - ADAMTSL2
ExoCarta ExoCarta_9719
Vesiclepedia VP_9719
Entrez Gene 9719
HGNC 14631
MIM 612277
UniProt Q86TH1  
 ADAMTSL2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ADAMTSL2
Molecular Function
    metalloendopeptidase activity GO:0004222 IBA
    protein binding GO:0005515 IPI
    microfibril binding GO:0050436 IEA
Biological Process
    extracellular matrix organization GO:0030198 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IMP
    lobar bronchus epithelium development GO:0060481 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    extracellular matrix GO:0031012 IBA
 Experiment description of studies that identified ADAMTSL2 in sEVs
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ADAMTSL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FBLN1 2192
Two-hybrid Homo sapiens
View the network image/svg+xml



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