Gene description for HS3ST3A1
Gene name heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
Gene symbol HS3ST3A1
Other names/aliases 3-OST-3A
3OST3A1
Species Homo sapiens
 Database cross references - HS3ST3A1
ExoCarta ExoCarta_9955
Vesiclepedia VP_9955
Entrez Gene 9955
HGNC 5196
MIM 604057
UniProt Q9Y663  
 HS3ST3A1 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for HS3ST3A1
Molecular Function
    sulfotransferase activity GO:0008146 TAS
    [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity GO:0008467 IBA
    [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity GO:0008467 IDA
    [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity GO:0008467 TAS
    [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity GO:0033872 IEA
Biological Process
    branching involved in ureteric bud morphogenesis GO:0001658 IEA
    glycosaminoglycan biosynthetic process GO:0006024 IDA
    heparan sulfate proteoglycan biosynthetic process, enzymatic modification GO:0015015 TAS
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    membrane GO:0016020 TAS
 Experiment description of studies that identified HS3ST3A1 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HS3ST3A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIPSL 266971
Affinity Capture-MS Homo sapiens
2 UPF2 26019
Two-hybrid Homo sapiens
View the network image/svg+xml



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