Gene description for CDK5
Gene name cyclin-dependent kinase 5
Gene symbol CDK5
Other names/aliases LIS7
PSSALRE
Species Homo sapiens
 Database cross references - CDK5
ExoCarta ExoCarta_1020
Vesiclepedia VP_1020
Entrez Gene 1020
HGNC 1774
MIM 123831
UniProt Q00535  
 CDK5 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Neuroblastoma cells 25944692    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Thymus 23844026    
 Gene ontology annotations for CDK5
Molecular Function
    p53 binding GO:0002039 IEA
    protein kinase activity GO:0004672 TAS
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 ISS
    protein serine/threonine kinase activity GO:0004674 NAS
    protein serine/threonine kinase activity GO:0004674 TAS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 IBA
    cyclin-dependent protein serine/threonine kinase activity GO:0004693 TAS
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    ribosomal protein S6 kinase activity GO:0004711 IEA
    ErbB-2 class receptor binding GO:0005176 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 TAS
    kinase activity GO:0016301 ISS
    acetylcholine receptor activator activity GO:0030549 ISS
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    ErbB-3 class receptor binding GO:0043125 ISS
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    tau protein binding GO:0048156 NAS
    tau-protein kinase activity GO:0050321 ISS
    tau-protein kinase activity GO:0050321 NAS
    Hsp90 protein binding GO:0051879 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 TAS
    neuron migration GO:0001764 TAS
    synaptic transmission, dopaminergic GO:0001963 IEA
    chromatin remodeling GO:0006338 IEA
    protein phosphorylation GO:0006468 TAS
    intracellular protein transport GO:0006886 IEA
    cell-matrix adhesion GO:0007160 IEA
    chemical synaptic transmission GO:0007268 TAS
    axonogenesis GO:0007409 IBA
    synapse assembly GO:0007416 TAS
    skeletal muscle tissue development GO:0007519 IEA
    motor neuron axon guidance GO:0008045 IEA
    visual learning GO:0008542 IEA
    Schwann cell development GO:0014044 IEA
    synaptic vesicle exocytosis GO:0016079 TAS
    regulation of macroautophagy GO:0016241 TAS
    phosphorylation GO:0016310 IDA
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-serine phosphorylation GO:0018105 ISS
    peptidyl-threonine phosphorylation GO:0018107 ISS
    sensory perception of pain GO:0019233 IEA
    cerebellar cortex formation GO:0021697 IEA
    hippocampus development GO:0021766 IEA
    layer formation in cerebral cortex GO:0021819 IEA
    central nervous system neuron development GO:0021954 IEA
    corpus callosum development GO:0022038 IEA
    actin cytoskeleton organization GO:0030036 TAS
    neuron differentiation GO:0030182 ISS
    neuron differentiation GO:0030182 TAS
    regulation of cell migration GO:0030334 IEA
    negative regulation of axon extension GO:0030517 IEA
    neuron projection development GO:0031175 ISS
    neuron projection development GO:0031175 TAS
    negative regulation of protein ubiquitination GO:0031397 IEA
    negative regulation of synaptic plasticity GO:0031914 IEA
    receptor catabolic process GO:0032801 IEA
    synaptic transmission, glutamatergic GO:0035249 IEA
    protein localization to synapse GO:0035418 IEA
    regulation of apoptotic process GO:0042981 TAS
    receptor clustering GO:0043113 IEA
    positive regulation of neuron apoptotic process GO:0043525 ISS
    negative regulation of cell cycle GO:0045786 IEA
    negative regulation of proteolysis GO:0045861 IMP
    negative regulation of DNA-templated transcription GO:0045892 IMP
    positive regulation of calcium ion-dependent exocytosis GO:0045956 IEA
    negative regulation of protein export from nucleus GO:0046826 IEA
    behavioral response to cocaine GO:0048148 IEA
    regulation of synaptic plasticity GO:0048167 ISS
    regulation of synaptic plasticity GO:0048167 TAS
    synaptic vesicle endocytosis GO:0048488 TAS
    synaptic vesicle transport GO:0048489 IBA
    rhythmic process GO:0048511 IEA
    axon extension GO:0048675 TAS
    oligodendrocyte differentiation GO:0048709 IDA
    dendrite morphogenesis GO:0048813 IEA
    cell division GO:0051301 IEA
    neuron apoptotic process GO:0051402 IBA
    neuron apoptotic process GO:0051402 TAS
    regulation of cell cycle GO:0051726 TAS
    regulation of synaptic transmission, glutamatergic GO:0051966 ISS
    excitatory postsynaptic potential GO:0060079 IEA
    regulation of dendritic spine morphogenesis GO:0061001 ISS
    calcium ion import GO:0070509 IEA
    positive regulation of protein targeting to membrane GO:0090314 IEA
    regulation of cell cycle phase transition GO:1901987 IBA
    regulation of protein localization to plasma membrane GO:1903076 ISS
    regulation of synaptic vesicle recycling GO:1903421 NAS
    cellular response to amyloid-beta GO:1904646 ISS
Subcellular Localization
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 IPI
    cyclin-dependent protein kinase holoenzyme complex GO:0000307 ISS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 TAS
    microtubule GO:0005874 ISS
    plasma membrane GO:0005886 IDA
    postsynaptic density GO:0014069 ISS
    membrane GO:0016020 ISS
    protein kinase 5 complex GO:0016533 IPI
    protein kinase 5 complex GO:0016533 ISS
    lamellipodium GO:0030027 IEA
    cell junction GO:0030054 IDA
    filopodium GO:0030175 IEA
    axon GO:0030424 ISS
    dendrite GO:0030425 ISS
    growth cone GO:0030426 ISS
    neuromuscular junction GO:0031594 ISS
    neuron projection GO:0043005 ISS
    neuronal cell body GO:0043025 ISS
    perikaryon GO:0043204 IEA
    presynapse GO:0098793 IEA
 Experiment description of studies that identified CDK5 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
10
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CDK5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
3 TUSC2  
Affinity Capture-MS Homo sapiens
4 HDAC4  
Affinity Capture-Western Homo sapiens
5 Cdk1 12534
Affinity Capture-MS Mus musculus
6 GLUD1 2746
Affinity Capture-MS Homo sapiens
7 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CDK3 1018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CCNI2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CABLES2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RPA2 6118
Proximity Label-MS Homo sapiens
12 SUB1 10923
Affinity Capture-MS Homo sapiens
13 GAK 2580
Affinity Capture-Western Homo sapiens
14 DCLK3  
Affinity Capture-MS Homo sapiens
15 DAB1 1600
Biochemical Activity Homo sapiens
16 CDC25B 994
Biochemical Activity Homo sapiens
17 CCT4 10575
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
19 CHFR  
Affinity Capture-MS Homo sapiens
20 Suds3  
Biochemical Activity Mus musculus
21 APP 351
Reconstituted Complex Homo sapiens
22 HIST1H1A 3024
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
23 STX1A 6804
Reconstituted Complex Homo sapiens
24 CDK14 5218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 Nedd4 25489
Biochemical Activity Rattus norvegicus
Reconstituted Complex Rattus norvegicus
26 TLN1 7094
Biochemical Activity Homo sapiens
27 FZR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
28 DRG1 4733
Affinity Capture-MS Homo sapiens
29 STIP1 10963
Affinity Capture-MS Homo sapiens
30 MBP 4155
Biochemical Activity Homo sapiens
31 TULP3 7289
Affinity Capture-MS Homo sapiens
32 FIBP 9158
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SARNP 84324
Affinity Capture-MS Homo sapiens
34 HIST1H1C 3006
Cross-Linking-MS (XL-MS) Homo sapiens
35 RPL34 6164
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
36 DNM1 1759
Biochemical Activity Homo sapiens
37 NEDD4 4734
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
38 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 TRAP1 10131
Affinity Capture-MS Homo sapiens
40 TRIM59  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
41 PAK1 5058
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
42 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RB1 5925
Biochemical Activity Homo sapiens
44 ALAS1  
Two-hybrid Homo sapiens
45 NF2 4771
Affinity Capture-MS Homo sapiens
46 CDK16 5127
Biochemical Activity Homo sapiens
47 TCP1 6950
Affinity Capture-MS Homo sapiens
48 MIB1 57534
Proximity Label-MS Homo sapiens
49 CDK2 1017
Affinity Capture-MS Homo sapiens
50 RNF32  
Two-hybrid Homo sapiens
51 CDKN1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 PARK2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
53 CDK5 1020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 CCT6A 908
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MCAM 4162
Proximity Label-MS Homo sapiens
56 BAG6 7917
Two-hybrid Homo sapiens
57 RPE  
Co-fractionation Homo sapiens
58 CCNB1 891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 MAPT  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
60 SPDYA  
Two-hybrid Homo sapiens
61 NTRK1 4914
Affinity Capture-MS Homo sapiens
62 GORASP2 26003
Affinity Capture-MS Homo sapiens
63 HIST1H1E 3008
Cross-Linking-MS (XL-MS) Homo sapiens
64 PIKFYVE 200576
Biochemical Activity Homo sapiens
65 CDK5R1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
66 MEOX2  
Two-hybrid Homo sapiens
67 CHORDC1 26973
Affinity Capture-MS Homo sapiens
68 ARRDC3 57561
Affinity Capture-MS Homo sapiens
69 SPDYE4  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
70 HECTD1 25831
Affinity Capture-MS Homo sapiens
71 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
72 CCNO  
Affinity Capture-MS Homo sapiens
73 SH3GLB1 51100
Affinity Capture-MS Homo sapiens
74 CCNA2 890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 PSEN1 5663
Two-hybrid Homo sapiens
76 HTRA2 27429
Biochemical Activity Homo sapiens
77 GRM5  
Affinity Capture-Western Homo sapiens
78 NUBP2 10101
Co-fractionation Homo sapiens
79 ECT2 1894
Affinity Capture-MS Homo sapiens
80 PPARG 5468
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
81 STXBP1 6812
Affinity Capture-Western Homo sapiens
82 PRCC  
Affinity Capture-MS Homo sapiens
83 LMTK2 22853
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
84 CCNE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 EGFR 1956
Affinity Capture-MS Homo sapiens
86 H1F0 3005
Biochemical Activity Homo sapiens
87 SEPT11 55752
Affinity Capture-MS Homo sapiens
88 KIF26B  
Biochemical Activity Homo sapiens
89 SCYL2 55681
Affinity Capture-MS Homo sapiens
90 AMPH 273
Biochemical Activity Homo sapiens
91 CDK5RAP2 55755
Reconstituted Complex Homo sapiens
92 FASN 2194
Negative Genetic Homo sapiens
93 C2CD5 9847
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 RPA3 6119
Proximity Label-MS Homo sapiens
95 DIS3 22894
Affinity Capture-MS Homo sapiens
96 CABLES1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 CDK20  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 SEPT7 989
Affinity Capture-MS Homo sapiens
99 CDKN1B 1027
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 CCND1 595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 KIAA0195 9772
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 NEDD4L 23327
Biochemical Activity Homo sapiens
103 STUB1 10273
Affinity Capture-Western Homo sapiens
104 NES 10763
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
105 CDC25A  
Biochemical Activity Homo sapiens
106 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
107 FBXW11  
Affinity Capture-MS Homo sapiens
108 COPZ1 22818
Affinity Capture-MS Homo sapiens
109 CCT8 10694
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 CCND2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
112 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 UNC119B 84747
Affinity Capture-MS Homo sapiens
114 GBP1 2633
Co-fractionation Homo sapiens
115 CDC37 11140
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
116 AURKC  
Affinity Capture-MS Homo sapiens
117 CDK18 5129
Affinity Capture-MS Homo sapiens
118 MDGA1  
Affinity Capture-MS Homo sapiens
119 CDC25C  
Biochemical Activity Homo sapiens
120 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
121 HTR6  
Affinity Capture-MS Homo sapiens
122 PCNA 5111
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
123 CCNI 10983
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 LRRK2 120892
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
125 YBX3 8531
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
126 NDEL1 81565
Co-localization Homo sapiens
Biochemical Activity Homo sapiens
127 EPHA2 1969
Proximity Label-MS Homo sapiens
128 SERBP1 26135
Affinity Capture-MS Homo sapiens
129 C9orf72  
Affinity Capture-MS Homo sapiens
130 ODF1  
Affinity Capture-Western Homo sapiens
131 MAST1  
Two-hybrid Homo sapiens
132 RSPRY1 89970
Affinity Capture-MS Homo sapiens
133 AATK  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
134 CNPPD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 CCND3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CDK5 is involved
PathwayEvidenceSource
Activated NTRK2 signals through CDK5 IEA Reactome
Axon guidance TAS Reactome
Axon guidance IEA Reactome
CRMPs in Sema3A signaling TAS Reactome
CRMPs in Sema3A signaling IEA Reactome
DARPP-32 events TAS Reactome
Defective Intrinsic Pathway for Apoptosis TAS Reactome
Defective Intrinsic Pathway for Apoptosis IEA Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models TAS Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models IEA Reactome
Developmental Biology TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases of programmed cell death TAS Reactome
Diseases of programmed cell death IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
Factors involved in megakaryocyte development and platelet production IEA Reactome
G alpha (i) signalling events TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway IEA Reactome
Generic Transcription Pathway TAS Reactome
GPCR downstream signalling TAS Reactome
Hemostasis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Nervous system development TAS Reactome
Nervous system development IEA Reactome
Neurodegenerative Diseases TAS Reactome
Neurodegenerative Diseases IEA Reactome
NGF-stimulated transcription IEA Reactome
NPAS4 regulates expression of target genes IEA Reactome
Nuclear Events (kinase and transcription factor activation) IEA Reactome
Opioid Signalling TAS Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Phosphorylation TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RNA Polymerase II Transcription TAS Reactome
Semaphorin interactions TAS Reactome
Semaphorin interactions IEA Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by NTRK1 (TRKA) IEA Reactome
Signaling by NTRK2 (TRKB) IEA Reactome
Signaling by NTRKs IEA Reactome
Signaling by Receptor Tyrosine Kinases IEA Reactome
Transcriptional Regulation by NPAS4 IEA Reactome
Transcriptional Regulation by TP53 TAS Reactome





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