Gene description for Pdcd1
Gene name programmed cell death 1
Gene symbol Pdcd1
Other names/aliases Ly101
PD-1
Pdc1
Species Mus musculus
 Database cross references - Pdcd1
ExoCarta ExoCarta_18566
Vesiclepedia VP_18566
Entrez Gene 18566
UniProt Q02242  
 Pdcd1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pdcd1
Molecular Function
    protein binding GO:0005515 IPI
    signaling receptor activity GO:0038023 ISO
    signaling receptor activity GO:0038023 ISS
Biological Process
    B cell apoptotic process GO:0001783 IMP
    adaptive immune response GO:0002250 IEA
    negative regulation of tolerance induction GO:0002644 IMP
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 IEA
    negative regulation of T cell mediated immune response to tumor cell GO:0002841 ISO
    negative regulation of B cell apoptotic process GO:0002903 IMP
    regulation of immune response GO:0050776 IBA
    negative regulation of immune response GO:0050777 IMP
    negative regulation of T cell activation GO:0050868 ISO
    negative regulation of T cell activation GO:0050868 ISS
    positive regulation of T cell apoptotic process GO:0070234 IBA
    positive regulation of T cell apoptotic process GO:0070234 IMP
    regulatory T cell apoptotic process GO:1902482 IMP
Subcellular Localization
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 IDA
 Experiment description of studies that identified Pdcd1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pdcd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Usp5 22225
Affinity Capture-Western Mus musculus
2 Mdm2  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
View the network image/svg+xml
 Pathways in which Pdcd1 is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Costimulation by the CD28 family IEA Reactome
Immune System IEA Reactome
PD-1 signaling IEA Reactome





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