Gene description for Strap
Gene name serine/threonine kinase receptor associated protein
Gene symbol Strap
Other names/aliases AW557906
C78091
C79202
Unrip
Species Mus musculus
 Database cross references - Strap
ExoCarta ExoCarta_20901
Vesiclepedia VP_20901
Entrez Gene 20901
UniProt Q9Z1Z2  
 Strap identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Strap
Molecular Function
    RNA binding GO:0003723 IBA
    mRNA binding GO:0003729 IDA
    signaling receptor binding GO:0005102 IDA
    protein binding GO:0005515 IPI
    U2 snRNP binding GO:1990447 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    alternative mRNA splicing, via spliceosome GO:0000380 IMP
    alternative mRNA splicing, via spliceosome GO:0000380 ISO
    spliceosomal snRNP assembly GO:0000387 IBA
    spliceosomal snRNP assembly GO:0000387 ISO
    spliceosomal snRNP assembly GO:0000387 ISS
    protein-RNA complex assembly GO:0022618 IMP
    neuron differentiation GO:0030182 IMP
    maintenance of gastrointestinal epithelium GO:0030277 IEA
    maintenance of gastrointestinal epithelium GO:0030277 ISO
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    anatomical structure development GO:0048856 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    SMN complex GO:0032797 IBA
    SMN complex GO:0032797 ISO
    SMN complex GO:0032797 ISS
    SMN-Sm protein complex GO:0034719 ISO
    SMN-Sm protein complex GO:0034719 ISS
 Experiment description of studies that identified Strap in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Strap
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fxr1 14359
Affinity Capture-MS Mus musculus
2 Sgta 52551
Co-fractionation Mus musculus
3 Capza1 12340
Co-fractionation Mus musculus
4 Fmr1  
Co-fractionation Mus musculus
5 Foxp3  
Affinity Capture-MS Mus musculus
6 Snrpd3 67332
Co-fractionation Mus musculus
7 Lmna 16905
Affinity Capture-MS Mus musculus
8 Map1b 17755
Affinity Capture-Western Mus musculus
Co-fractionation Mus musculus
9 SMURF1 57154
Affinity Capture-Luminescence Homo sapiens
10 Snrpd2 107686
Co-fractionation Mus musculus
11 Snrpd1 20641
Co-fractionation Mus musculus
12 Aco1 11428
Co-fractionation Mus musculus
13 Nme1 18102
Co-fractionation Mus musculus
14 Capza2 12343
Co-fractionation Mus musculus
15 Fancd2  
Affinity Capture-MS Mus musculus
16 1700021F05Rik  
Co-fractionation Mus musculus
View the network image/svg+xml



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