Gene description for ADGRL3
Gene name adhesion G protein-coupled receptor L3
Gene symbol ADGRL3
Other names/aliases CIRL3
LEC3
LPHN3
Species Homo sapiens
 Database cross references - ADGRL3
ExoCarta ExoCarta_23284
Vesiclepedia VP_23284
Entrez Gene 23284
HGNC 20974
UniProt Q9HAR2  
 ADGRL3 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ADGRL3
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    G protein-coupled receptor activity GO:0004930 NAS
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
Biological Process
    neuron migration GO:0001764 ISS
    cell surface receptor signaling pathway GO:0007166 IEA
    G protein-coupled receptor signaling pathway GO:0007186 NAS
    adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA
    synapse assembly GO:0007416 IBA
    synapse assembly GO:0007416 ISS
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IBA
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cell-cell junction GO:0005911 IBA
    cell-cell junction GO:0005911 ISS
    membrane GO:0016020 NAS
    axon GO:0030424 IBA
    axon GO:0030424 ISS
    glutamatergic synapse GO:0098978 IBA
 Experiment description of studies that identified ADGRL3 in sEVs
1
Experiment ID 211
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADGRL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLRT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MARCH1  
Affinity Capture-MS Homo sapiens
3 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SUN3  
Affinity Capture-MS Homo sapiens
5 CLEC2D  
Affinity Capture-MS Homo sapiens
6 TMEM169  
Affinity Capture-MS Homo sapiens
7 MMP26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ASGR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MPL 4352
Affinity Capture-MS Homo sapiens
10 SLC22A4 6583
Affinity Capture-MS Homo sapiens
11 GP5 2814
Affinity Capture-MS Homo sapiens
12 LGALS1 3956
Affinity Capture-MS Homo sapiens
13 TMEM9 252839
Affinity Capture-MS Homo sapiens
14 KRTCAP3 200634
Affinity Capture-MS Homo sapiens
15 ATP1B1 481
Affinity Capture-MS Homo sapiens
16 HYPM  
Affinity Capture-MS Homo sapiens
17 C3AR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 YIPF3 25844
Affinity Capture-MS Homo sapiens
19 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADGRL3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here