Gene description for CHRDL2
Gene name chordin-like 2
Gene symbol CHRDL2
Other names/aliases BNF1
CHL2
Species Homo sapiens
 Database cross references - CHRDL2
ExoCarta ExoCarta_25884
Vesiclepedia VP_25884
Entrez Gene 25884
HGNC 24168
MIM 613127
UniProt Q6WN34  
 CHRDL2 identified in sEVs derived from the following tissue/cell type
Breast milk 17641064    
 Gene ontology annotations for CHRDL2
Molecular Function
    protein binding GO:0005515 IPI
    BMP binding GO:0036122 IBA
Biological Process
    ossification GO:0001503 IEA
    cell differentiation GO:0030154 IBA
    negative regulation of BMP signaling pathway GO:0030514 IBA
    cartilage development GO:0051216 IEA
Subcellular Localization
    extracellular space GO:0005615 HDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified CHRDL2 in sEVs
1
Experiment ID 48
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17641064    
Organism Homo sapiens
Experiment description Exosomes with immune modulatory features are present in human breast milk.
Authors "Admyre C, Johansson SM, Qazi KR, Filen JJ, Lahesmaa R, Norman M, Neve EP, Scheynius A, Gabrielsson S"
Journal name JIMMU
Publication year 2007
Sample Breast milk
Sample name Breast milk - Mature milk
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density 1.10-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
FACS
 Protein-protein interactions for CHRDL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBR2 23304
Affinity Capture-MS Homo sapiens
2 IGHG3 3502
Affinity Capture-MS Homo sapiens
3 C3 718
Affinity Capture-MS Homo sapiens
4 RMND5A 64795
Affinity Capture-MS Homo sapiens
5 ZMYND19  
Affinity Capture-MS Homo sapiens
6 RANBP9 10048
Affinity Capture-MS Homo sapiens
7 ACTA1 58
Affinity Capture-MS Homo sapiens
8 GID8 54994
Affinity Capture-MS Homo sapiens
9 GID4  
Affinity Capture-MS Homo sapiens
10 MKLN1  
Affinity Capture-MS Homo sapiens
11 FGG 2266
Affinity Capture-MS Homo sapiens
12 FGB 2244
Affinity Capture-MS Homo sapiens
13 C19orf80  
Affinity Capture-MS Homo sapiens
14 FGA 2243
Affinity Capture-MS Homo sapiens
15 RANBP10 57610
Affinity Capture-MS Homo sapiens
16 INHBA 3624
Reconstituted Complex Homo sapiens
17 MAEA 10296
Affinity Capture-MS Homo sapiens
18 WDR26 80232
Affinity Capture-MS Homo sapiens
19 ARMC8 25852
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CHRDL2 is involved
No pathways found





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