Gene description for FGB
Gene name fibrinogen beta chain
Gene symbol FGB
Other names/aliases HEL-S-78p
Species Homo sapiens
 Database cross references - FGB
ExoCarta ExoCarta_2244
Vesiclepedia VP_2244
Entrez Gene 2244
HGNC 3662
MIM 134830
UniProt P02675  
 FGB identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Hepatocellular carcinoma cells 26054723    
Malignant pleural effusions 14975938    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Plasma 19028452    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Synovial fluid 17133577    
Synovial fluid 17133577    
Thymus 23844026    
 Gene ontology annotations for FGB
Molecular Function
    signaling receptor binding GO:0005102 IDA
    structural molecule activity GO:0005198 IDA
    extracellular matrix structural constituent GO:0005201 HDA
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    cell adhesion molecule binding GO:0050839 IDA
    protein-folding chaperone binding GO:0051087 IPI
Biological Process
    adaptive immune response GO:0002250 IEA
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IDA
    plasminogen activation GO:0031639 IDA
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IDA
    fibrinolysis GO:0042730 IDA
    induction of bacterial agglutination GO:0043152 IDA
    cellular response to leptin stimulus GO:0044320 IEA
    innate immune response GO:0045087 IEA
    positive regulation of vasoconstriction GO:0045907 IDA
    positive regulation of exocytosis GO:0045921 IDA
    positive regulation of protein secretion GO:0050714 IDA
    protein polymerization GO:0051258 IDA
    response to calcium ion GO:0051592 IDA
    protein-containing complex assembly GO:0065003 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    platelet aggregation GO:0070527 IBA
    platelet aggregation GO:0070527 IDA
    cellular response to interleukin-1 GO:0071347 IEA
    blood coagulation, fibrin clot formation GO:0072378 IBA
    blood coagulation, fibrin clot formation GO:0072378 IDA
    positive regulation of peptide hormone secretion GO:0090277 IDA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 NAS
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IDA
    negative regulation of endothelial cell apoptotic process GO:2000352 IDA
Subcellular Localization
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    fibrinogen complex GO:0005577 IDA
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 TAS
    cell cortex GO:0005938 IEA
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    platelet alpha granule GO:0031091 IDA
    platelet alpha granule lumen GO:0031093 TAS
    synapse GO:0045202 IEA
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IBA
    extracellular exosome GO:0070062 HDA
    blood microparticle GO:0072562 HDA
    extracellular vesicle GO:1903561 HDA
 Experiment description of studies that identified FGB in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
10
Experiment ID 53
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors "Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN"
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Mesothelioma
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
11
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
12
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 44
MISEV standards
✔
IEM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
14
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
18
Experiment ID 62
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17133577    
Organism Mus musculus
Experiment description Association of citrullinated proteins with synovial exosomes.
Authors "Skriner K, Adolph K, Jungblut PR, Burmester GR"
Journal name AR
Publication year 2006
Sample Synovial fluid
Sample name Synovial fluid - Rheumatoid arthritis
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Immunoelectron Microscopy
Mass spectrometry [MALDI TOF]
Western blotting
19
Experiment ID 61
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17133577    
Organism Mus musculus
Experiment description Association of citrullinated proteins with synovial exosomes.
Authors "Skriner K, Adolph K, Jungblut PR, Burmester GR"
Journal name AR
Publication year 2006
Sample Synovial fluid
Sample name Synovial fluid - Osteoarthritis and reactive arthritis
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Immunoelectron Microscopy
Mass spectrometry [MALDI TOF]
Western blotting
20
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FGB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MIS12  
Affinity Capture-MS Homo sapiens
2 PSME2 5721
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 GTF2F1 2962
Affinity Capture-MS Homo sapiens
4 ARHGAP1 392
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 FTO 79068
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 SNX3 8724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 STATH  
Affinity Capture-MS Homo sapiens
8 TK1 7083
Two-hybrid Homo sapiens
9 DENR 8562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DDAH1 23576
Affinity Capture-MS Homo sapiens
11 GC 2638
Affinity Capture-MS Homo sapiens
12 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TLN1 7094
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 PAK2 5062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 RBM12 10137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PIR 8544
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SNX6 58533
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SOX2  
Affinity Capture-MS Homo sapiens
20 SBDS 51119
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CAB39 51719
Affinity Capture-MS Homo sapiens
22 RHBDD1 84236
Affinity Capture-MS Homo sapiens
23 UBA1 7317
Affinity Capture-MS Homo sapiens
24 HPX 3263
Affinity Capture-MS Homo sapiens
25 ADK 132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 VPS26A 9559
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 HP 3240
Affinity Capture-MS Homo sapiens
28 WHSC1 7468
Affinity Capture-MS Homo sapiens
29 USO1 8615
Affinity Capture-MS Homo sapiens
30 CLU 1191
Affinity Capture-MS Homo sapiens
31 ORM1 5004
Affinity Capture-MS Homo sapiens
32 TBC1D24 57465
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 EGFL8  
Affinity Capture-MS Homo sapiens
34 NID1 4811
Reconstituted Complex Homo sapiens
35 C4orf27  
Affinity Capture-MS Homo sapiens
36 MCTS1 28985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ARMT1 79624
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 NARS 4677
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CTH 1491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 RHOA 387
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 CHORDC1 26973
Affinity Capture-MS Homo sapiens
42 PHF11 51131
Affinity Capture-MS Homo sapiens
43 A2M 2
Cross-Linking-MS (XL-MS) Homo sapiens
44 FNDC1 84624
Affinity Capture-MS Homo sapiens
45 NME2 4831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SERPINA1 5265
Affinity Capture-MS Homo sapiens
47 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TF 7018
Affinity Capture-MS Homo sapiens
49 CSNK2B 1460
Two-hybrid Homo sapiens
50 C18orf21  
Affinity Capture-MS Homo sapiens
51 LSM1 27257
Affinity Capture-MS Homo sapiens
52 TES 26136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 GCA 25801
Affinity Capture-MS Homo sapiens
54 FEN1 2237
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 ADSL 158
Affinity Capture-MS Homo sapiens
56 PAK1 5058
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 ANXA7 310
Two-hybrid Homo sapiens
59 GNG8  
Affinity Capture-MS Homo sapiens
60 CHMP1A 5119
Affinity Capture-MS Homo sapiens
61 DBNL 28988
Affinity Capture-MS Homo sapiens
62 UBE2T  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 NAA50 80218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 FBLN1 2192
Reconstituted Complex Homo sapiens
65 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
66 CDKN1A  
Two-hybrid Homo sapiens
67 FGA 2243
Co-crystal Structure Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
68 SLC9A5  
Affinity Capture-MS Homo sapiens
69 BTF3L4 91408
Affinity Capture-MS Homo sapiens
70 CERS3  
Affinity Capture-MS Homo sapiens
71 EIF2A 83939
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CHRDL2 25884
Affinity Capture-MS Homo sapiens
73 CAST 831
Affinity Capture-MS Homo sapiens
74 LETM1 3954
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 VRK1 7443
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 SP110  
Affinity Capture-MS Homo sapiens
77 FGG 2266
Co-crystal Structure Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
78 PYGB 5834
Affinity Capture-MS Homo sapiens
79 SARAF  
Affinity Capture-MS Homo sapiens
80 PIGT 51604
Affinity Capture-MS Homo sapiens
81 SPR 6697
Affinity Capture-MS Homo sapiens
82 SSUH2  
Affinity Capture-MS Homo sapiens
83 YWHAQ 10971
Affinity Capture-MS Homo sapiens
84 PRR4 11272
Affinity Capture-MS Homo sapiens
85 GPKOW  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 DDX1 1653
Affinity Capture-MS Homo sapiens
87 SERPINA3 12
Affinity Capture-MS Homo sapiens
88 CTNNBL1 56259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 AIMP2 7965
Two-hybrid Homo sapiens
90 ARFGAP1 55738
Affinity Capture-MS Homo sapiens
91 PTPN11 5781
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 PBK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 RING1 6015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 TMPO 7112
Affinity Capture-MS Homo sapiens
95 SCRN1 9805
Affinity Capture-MS Homo sapiens
96 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
97 PAPSS1 9061
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 BLVRB 645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 AGPAT1 10554
Affinity Capture-MS Homo sapiens
100 RNF181  
Two-hybrid Homo sapiens
101 GNAQ 2776
Affinity Capture-MS Homo sapiens
102 SAR1B 51128
Affinity Capture-MS Homo sapiens
103 CCNYL1 151195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ASCC1 51008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 TBCE 6905
Affinity Capture-MS Homo sapiens
106 HMGCS1 3157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 PPID 5481
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 LPA 4018
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
109 NAA15 80155
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 ASB6 140459
Affinity Capture-MS Homo sapiens
111 CP 1356
Affinity Capture-MS Homo sapiens
112 SLK 9748
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 ETF1 2107
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 WIBG 84305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 PUS7 54517
Affinity Capture-MS Homo sapiens
116 SF3A1 10291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 PRKCI 5584
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 FARSB 10056
Affinity Capture-MS Homo sapiens
119 MAPK6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 KIAA1143  
Affinity Capture-MS Homo sapiens
122 TMEM237 65062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 DIS3 22894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 EEF1A2 1917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
125 ATPAF2 91647
Affinity Capture-MS Homo sapiens
126 HDLBP 3069
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 PNPO 55163
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 TCEA1 6917
Affinity Capture-MS Homo sapiens
129 RPRD1A  
Affinity Capture-MS Homo sapiens
130 FAM188A 80013
Affinity Capture-MS Homo sapiens
131 STX17 55014
Affinity Capture-MS Homo sapiens
132 RIPPLY3  
Affinity Capture-MS Homo sapiens
133 UBE2U  
Affinity Capture-MS Homo sapiens
134 CALR 811
Affinity Capture-MS Homo sapiens
135 APP 351
Reconstituted Complex Homo sapiens
136 CIR1  
Affinity Capture-MS Homo sapiens
137 GLS 2744
Affinity Capture-MS Homo sapiens
138 KIF2A 3796
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 LZIC 84328
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 SMN1 6606
Two-hybrid Homo sapiens
141 SLC25A6 293
Affinity Capture-MS Homo sapiens
142 PAPOLA 10914
Affinity Capture-MS Homo sapiens
143 SCGB1D1  
Affinity Capture-MS Homo sapiens
144 SYAP1 94056
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 DUSP3 1845
Affinity Capture-MS Homo sapiens
146 GRB7 2886
Two-hybrid Homo sapiens
147 LGALS3 3958
Affinity Capture-MS Homo sapiens
148 NME2P1 283458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
149 CCR1  
Affinity Capture-MS Homo sapiens
150 OXSR1 9943
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
151 SSBP2  
Affinity Capture-MS Homo sapiens
152 COL18A1 80781
Cross-Linking-MS (XL-MS) Homo sapiens
153 OTUB1 55611
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 GNL1 2794
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 MAP2K1 5604
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 PDE6D 5147
Affinity Capture-MS Homo sapiens
157 POU2F1 5451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
158 UFL1 23376
Two-hybrid Homo sapiens
159 KHDRBS2  
Affinity Capture-MS Homo sapiens
160 MBNL1 4154
Affinity Capture-MS Homo sapiens
161 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
162 EIF3J 8669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 KLK10 5655
Affinity Capture-MS Homo sapiens
164 PMVK 10654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 ITPA 3704
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 TRIM31  
Affinity Capture-MS Homo sapiens
167 PINK1  
Affinity Capture-MS Homo sapiens
168 GOT1 2805
Affinity Capture-MS Homo sapiens
169 RPRD1B 58490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 GLRX3 10539
Affinity Capture-MS Homo sapiens
171 UBLCP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 SLC6A1  
Affinity Capture-MS Homo sapiens
173 CYP3A43  
Affinity Capture-MS Homo sapiens
174 P2RX6  
Affinity Capture-MS Homo sapiens
175 ASB7  
Affinity Capture-MS Homo sapiens
176 ATG3 64422
Affinity Capture-MS Homo sapiens
177 XPNPEP1 7511
Affinity Capture-MS Homo sapiens
178 PIK3R3 8503
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which FGB is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Antigen processing-Cross presentation TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Common Pathway of Fibrin Clot Formation TAS Reactome
Disease TAS Reactome
Diseases associated with the TLR signaling cascade TAS Reactome
Diseases of Immune System TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
ER-Phagosome pathway TAS Reactome
Extracellular matrix organization TAS Reactome
Formation of Fibrin Clot (Clotting Cascade) TAS Reactome
GRB2:SOS provides linkage to MAPK signaling for Integrins TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Integrin cell surface interactions TAS Reactome
Integrin signaling TAS Reactome
IRAK4 deficiency (TLR2/4) TAS Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
MyD88 deficiency (TLR2/4) TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Oncogenic MAPK signaling TAS Reactome
p130Cas linkage to MAPK signaling for integrins TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Platelet degranulation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of TLR by endogenous ligand TAS Reactome
Response to elevated platelet cytosolic Ca2+ TAS Reactome
Signal Transduction TAS Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome





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