Gene description for TK1
Gene name thymidine kinase 1, soluble
Gene symbol TK1
Other names/aliases TK2
Species Homo sapiens
 Database cross references - TK1
ExoCarta ExoCarta_7083
Vesiclepedia VP_7083
Entrez Gene 7083
HGNC 11830
MIM 188300
UniProt P04183  
 TK1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for TK1
Molecular Function
    thymidine kinase activity GO:0004797 IBA
    thymidine kinase activity GO:0004797 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    zinc ion binding GO:0008270 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    nucleobase-containing compound metabolic process GO:0006139 TAS
    deoxyribonucleoside monophosphate biosynthetic process GO:0009157 IEA
    thymidine metabolic process GO:0046104 IBA
    thymidine metabolic process GO:0046104 IDA
    thymidine biosynthetic process GO:0046105 IDA
    protein homotetramerization GO:0051289 IDA
    protein homotetramerization GO:0051289 IPI
    DNA synthesis involved in mitotic DNA replication GO:1904860 IDA
Subcellular Localization
    nucleus GO:0005634 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified TK1 in sEVs
1
Experiment ID 489
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 235
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
7
Experiment ID 488
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CENPB 1059
Two-hybrid Homo sapiens
3 A1BG 1
Two-hybrid Homo sapiens
4 APLP1 333
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 CLEC3B 7123
Two-hybrid Homo sapiens
6 BOLA2 552900
Two-hybrid Homo sapiens
7 JADE1  
Two-hybrid Homo sapiens
8 FBN3 84467
Two-hybrid Homo sapiens
9 QARS 5859
Two-hybrid Homo sapiens
10 JMJD1C 221037
Two-hybrid Homo sapiens
11 TK1 7083
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
12 ATP6V1A 523
Two-hybrid Homo sapiens
13 TSC2 7249
Two-hybrid Homo sapiens
14 ZXDC  
Two-hybrid Homo sapiens
15 PKM 5315
Two-hybrid Homo sapiens
16 COL11A2 1302
Two-hybrid Homo sapiens
17 RPA2 6118
Proximity Label-MS Homo sapiens
18 GLB1 2720
Two-hybrid Homo sapiens
19 ALB 213
Two-hybrid Homo sapiens
20 BOLA2B 654483
Two-hybrid Homo sapiens
21 GDF9 2661
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 IGHM 3507
Two-hybrid Homo sapiens
23 DACT1 51339
Two-hybrid Homo sapiens
24 DYNC1I1  
Two-hybrid Homo sapiens
25 MRPL37 51253
Two-hybrid Homo sapiens
26 KLHL23  
Two-hybrid Homo sapiens
27 NCF1  
Affinity Capture-MS Homo sapiens
28 SETDB1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
29 APP 351
Reconstituted Complex Homo sapiens
30 CCDC90B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
31 CCDC43 124808
Affinity Capture-MS Homo sapiens
32 CPNE6 9362
Two-hybrid Homo sapiens
33 RBM48  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 RPS2 6187
Two-hybrid Homo sapiens
35 RUVBL1 8607
Two-hybrid Homo sapiens
36 MEI1  
Affinity Capture-MS Homo sapiens
37 KLHL24  
Affinity Capture-MS Homo sapiens
38 COPS6 10980
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
39 FZR1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
40 PTPN4  
Two-hybrid Homo sapiens
41 GDI1 2664
Two-hybrid Homo sapiens
42 ADD1 118
Two-hybrid Homo sapiens
43 USP4 7375
Two-hybrid Homo sapiens
44 DNAJB1 3337
Affinity Capture-MS Homo sapiens
45 TTC38 55020
Two-hybrid Homo sapiens
46 KDM6B 23135
Two-hybrid Homo sapiens
47 CHGB 1114
Two-hybrid Homo sapiens
48 FAF1 11124
Two-hybrid Homo sapiens
49 CRMP1 1400
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 PLA2G10  
Affinity Capture-MS Homo sapiens
51 SMC5 23137
Two-hybrid Homo sapiens
52 ZNF202  
Affinity Capture-MS Homo sapiens
53 MPP1 4354
Two-hybrid Homo sapiens
54 WIZ 58525
Two-hybrid Homo sapiens
55 METTL23  
Two-hybrid Homo sapiens
56 HMGXB3  
Two-hybrid Homo sapiens
57 HSPBAP1  
Two-hybrid Homo sapiens
58 FAM20C 56975
Two-hybrid Homo sapiens
59 EEF1A1 1915
Two-hybrid Homo sapiens
60 DVL2 1856
Affinity Capture-MS Homo sapiens
61 MSH2 4436
Two-hybrid Homo sapiens
62 BAG6 7917
Two-hybrid Homo sapiens
63 DUS2 54920
Two-hybrid Homo sapiens
64 ABHD4 63874
Two-hybrid Homo sapiens
65 AGAP1  
Two-hybrid Homo sapiens
66 C19orf60  
Two-hybrid Homo sapiens
67 ALAS1  
Two-hybrid Homo sapiens
68 SEZ6L2 26470
Two-hybrid Homo sapiens
69 PROC 5624
Two-hybrid Homo sapiens
70 ODC1 4953
Two-hybrid Homo sapiens
71 CDKN1A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
72 WDR73  
Two-hybrid Homo sapiens
73 ZBTB16  
Two-hybrid Homo sapiens
74 PSME1 5720
Two-hybrid Homo sapiens
75 A2M 2
Two-hybrid Homo sapiens
76 TUBA1A 7846
Two-hybrid Homo sapiens
77 LRIF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 MPPED1  
Two-hybrid Homo sapiens
79 ASNA1 439
Two-hybrid Homo sapiens
80 KIF5A 3798
Two-hybrid Homo sapiens
81 SP110  
Two-hybrid Homo sapiens
82 DRAP1 10589
Two-hybrid Homo sapiens
83 NGFR 4804
Two-hybrid Homo sapiens
84 ZNF131  
Affinity Capture-MS Homo sapiens
85 MOV10 4343
Affinity Capture-RNA Homo sapiens
86 NCS1 23413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 UNC119 9094
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
88 ACTB 60
Two-hybrid Homo sapiens
89 EZH2  
Two-hybrid Homo sapiens
90 PLXNA3 55558
Two-hybrid Homo sapiens
91 MED31  
Two-hybrid Homo sapiens
92 SDF4 51150
Two-hybrid Homo sapiens
93 ATP5B 506
Two-hybrid Homo sapiens
94 ARFGAP1 55738
Two-hybrid Homo sapiens
95 NKIRAS2  
Two-hybrid Homo sapiens
96 SEPT6 23157
Two-hybrid Homo sapiens
97 TYK2 7297
Two-hybrid Homo sapiens
98 EIF4A2 1974
Two-hybrid Homo sapiens
99 DDAH2 23564
Two-hybrid Homo sapiens
100 SEMA5B  
Two-hybrid Homo sapiens
101 SNX1 6642
Two-hybrid Homo sapiens
102 CCDC115 84317
Two-hybrid Homo sapiens
103 EIF3G 8666
Two-hybrid Homo sapiens
104 COL4A2 1284
Two-hybrid Homo sapiens
105 HADHB 3032
Two-hybrid Homo sapiens
106 C14orf1 11161
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
107 RPL13 6137
Two-hybrid Homo sapiens
108 EIF6 3692
Two-hybrid Homo sapiens
109 DOCK7 85440
Two-hybrid Homo sapiens
110 ZNF232  
Affinity Capture-MS Homo sapiens
111 ADAMTS10 81794
Two-hybrid Homo sapiens
112 CRYAB 1410
Affinity Capture-MS Homo sapiens
113 CUL3 8452
Affinity Capture-MS Homo sapiens
114 DCAF13 25879
Two-hybrid Homo sapiens
115 RBBP4 5928
Two-hybrid Homo sapiens
116 PM20D2 135293
Affinity Capture-MS Homo sapiens
117 FN1 2335
Affinity Capture-MS Homo sapiens
118 KIF21B 23046
Two-hybrid Homo sapiens
119 INPP5K 51763
Two-hybrid Homo sapiens
120 NRBP1 29959
Two-hybrid Homo sapiens
121 GPCPD1  
Two-hybrid Homo sapiens
122 EDA2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 RPA3 6119
Proximity Label-MS Homo sapiens
124 KLHL5  
Two-hybrid Homo sapiens
125 COL4A5  
Two-hybrid Homo sapiens
126 MAGEA4 4103
Two-hybrid Homo sapiens
127 MRFAP1  
Two-hybrid Homo sapiens
128 NMT2 9397
Two-hybrid Homo sapiens
129 ACTL6B  
Two-hybrid Homo sapiens
130 CARHSP1 23589
Two-hybrid Homo sapiens
131 LOC148413  
Two-hybrid Homo sapiens
132 NEUROD2  
Two-hybrid Homo sapiens
133 F13A1 2162
Two-hybrid Homo sapiens
134 CPSF3L 54973
Two-hybrid Homo sapiens
135 UPF2 26019
Two-hybrid Homo sapiens
136 TIAM2 26230
Two-hybrid Homo sapiens
137 KCNMB2  
Affinity Capture-MS Homo sapiens
138 TCTEX1D2  
Two-hybrid Homo sapiens
139 IMMT 10989
Two-hybrid Homo sapiens
140 TRIM46 80128
Two-hybrid Homo sapiens
141 TUBB2A 7280
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
142 DALRD3  
Two-hybrid Homo sapiens
143 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
144 PPP4C 5531
Two-hybrid Homo sapiens
145 CSAD 51380
Two-hybrid Homo sapiens
146 CDC20 991
Reconstituted Complex Homo sapiens
147 ITSN1 6453
Two-hybrid Homo sapiens
148 ATXN3 4287
Two-hybrid Homo sapiens
149 TP53 7157
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
150 THOC3  
Two-hybrid Homo sapiens
151 DEAF1 10522
Two-hybrid Homo sapiens
152 KMT2B  
Two-hybrid Homo sapiens
153 ATG16L2  
Two-hybrid Homo sapiens
154 CRIP1 1396
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 IER3IP1 51124
Two-hybrid Homo sapiens
156 RPA1 6117
Two-hybrid Homo sapiens
157 TLE1 7088
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
158 TRMT2A 27037
Two-hybrid Homo sapiens
159 FGB 2244
Two-hybrid Homo sapiens
160 TUBB3 10381
Two-hybrid Homo sapiens
161 SQSTM1 8878
Proximity Label-MS Homo sapiens
162 ACTR1B 10120
Two-hybrid Homo sapiens
163 MAMDC2 256691
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 PAAF1 80227
Two-hybrid Homo sapiens
165 MKI67  
Two-hybrid Homo sapiens
166 WDR18 57418
Two-hybrid Homo sapiens
167 FST 10468
Two-hybrid Homo sapiens
168 IGLL5 100423062
Affinity Capture-MS Homo sapiens
169 MAST2  
Two-hybrid Homo sapiens
170 SULT1A3 6818
Two-hybrid Homo sapiens
171 CRIP2 1397
Two-hybrid Homo sapiens
172 PLD3 23646
Two-hybrid Homo sapiens
173 BTBD1  
Affinity Capture-MS Homo sapiens
174 GAPDH 2597
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
175 EXT2 2132
Two-hybrid Homo sapiens
176 DMPK  
Two-hybrid Homo sapiens
177 LRRK2 120892
Affinity Capture-MS Homo sapiens
178 CDK4 1019
Two-hybrid Homo sapiens
179 RXRA 6256
Two-hybrid Homo sapiens
180 HERC3 8916
Two-hybrid Homo sapiens
181 TAF1C  
Two-hybrid Homo sapiens
182 PTPRK 5796
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
183 PDE4DIP 9659
Two-hybrid Homo sapiens
184 CUL7 9820
Affinity Capture-MS Homo sapiens
185 TMSB4X 7114
Two-hybrid Homo sapiens
186 SUMO3 6612
Two-hybrid Homo sapiens
187 ZNF431  
Two-hybrid Homo sapiens
188 AAMP 14
Two-hybrid Homo sapiens
189 FLAD1 80308
Two-hybrid Homo sapiens
190 WDR60 55112
Two-hybrid Homo sapiens
191 AGRP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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