Gene description for DVL2
Gene name	dishevelled segment polarity protein 2
Gene symbol	DVL2
Other names/aliases	-
Species	Homo sapiens
Database cross references - DVL2
ExoCarta	ExoCarta_1856
Vesiclepedia	VP_1856
Entrez Gene	1856
HGNC	3086
MIM	602151
UniProt	O14641
DVL2 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for DVL2

Molecular Function     frizzled binding GO:0005109 IBA     frizzled binding GO:0005109 IPI     frizzled binding GO:0005109 TAS     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IEA     protein domain specific binding GO:0019904 IEA     protein-macromolecule adaptor activity GO:0030674 IEA     small GTPase binding GO:0031267 IEA     identical protein binding GO:0042802 IPI Biological Process     neural tube closure GO:0001843 ISS     positive regulation of protein phosphorylation GO:0001934 IMP     heart looping GO:0001947 ISS     outflow tract morphogenesis GO:0003151 ISS     regulation of DNA-templated transcription GO:0006355 IDA     segment specification GO:0007379 ISS     heart development GO:0007507 ISS     protein localization GO:0008104 IEA     convergent extension involved in neural plate elongation GO:0022007 IEA     regulation of actin cytoskeleton organization GO:0032956 TAS     intracellular signal transduction GO:0035556 IEA     non-canonical Wnt signaling pathway GO:0035567 IMP     non-canonical Wnt signaling pathway GO:0035567 TAS     regulation of cell population proliferation GO:0042127 IDA     positive regulation of JUN kinase activity GO:0043507 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of JNK cascade GO:0046330 IMP     positive regulation of DNA-binding transcription factor activity GO:0051091 IDA     canonical Wnt signaling pathway GO:0060070 IBA     canonical Wnt signaling pathway GO:0060070 IDA     canonical Wnt signaling pathway GO:0060070 TAS     Wnt signaling pathway, planar cell polarity pathway GO:0060071 IDA     Wnt signaling pathway, planar cell polarity pathway GO:0060071 NAS     cochlea morphogenesis GO:0090103 IEA     positive regulation of neuron projection arborization GO:0150012 ISS Subcellular Localization     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IDA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 TAS     aggresome GO:0016235 IDA     lateral plasma membrane GO:0016328 IEA     nuclear body GO:0016604 IDA     cytoplasmic vesicle GO:0031410 IDA     apical part of cell GO:0045177 IEA     clathrin-coated endocytic vesicle GO:0045334 TAS