Gene description for PTEN
Gene name phosphatase and tensin homolog
Gene symbol PTEN
Other names/aliases 10q23del
BZS
CWS1
DEC
GLM2
MHAM
MMAC1
PTEN1
TEP1
Species Homo sapiens
 Database cross references - PTEN
ExoCarta ExoCarta_5728
Vesiclepedia VP_5728
Entrez Gene 5728
HGNC 9588
MIM 601728
UniProt P60484  
 PTEN identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTEN
Molecular Function
    phosphatidylinositol-3-phosphate phosphatase activity GO:0004438 IDA
    phosphoprotein phosphatase activity GO:0004721 IDA
    protein serine/threonine phosphatase activity GO:0004722 IDA
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IDA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    lipid binding GO:0008289 IEA
    anaphase-promoting complex binding GO:0010997 IPI
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0016314 IBA
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0016314 IDA
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0016314 TAS
    myosin phosphatase activity GO:0017018 IEA
    enzyme binding GO:0019899 IPI
    PDZ domain binding GO:0030165 IPI
    inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity GO:0030351 IDA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    identical protein binding GO:0042802 IPI
    inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051717 IDA
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity GO:0051800 IDA
    phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity GO:0051800 TAS
    phosphatidylinositol phosphate phosphatase activity GO:0052866 IDA
    molecular function inhibitor activity GO:0140678 IMP
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    ubiquitin-specific protease binding GO:1990381 IPI
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
    ubiquitin ligase activator activity GO:1990757 ISS
Biological Process
    negative regulation of protein phosphorylation GO:0001933 IDA
    negative regulation of protein phosphorylation GO:0001933 ISS
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    protein dephosphorylation GO:0006470 IDA
    protein dephosphorylation GO:0006470 TAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    apoptotic process GO:0006915 IEA
    spindle assembly involved in female meiosis GO:0007056 IDA
    neuron-neuron synaptic transmission GO:0007270 ISS
    synapse assembly GO:0007416 ISS
    central nervous system development GO:0007417 ISS
    heart development GO:0007507 ISS
    learning or memory GO:0007611 ISS
    locomotory behavior GO:0007626 ISS
    positive regulation of cell population proliferation GO:0008284 ISS
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of cell population proliferation GO:0008285 IMP
    negative regulation of epithelial to mesenchymal transition GO:0010719 IMP
    regulation of neuron projection development GO:0010975 ISS
    negative regulation of neuron projection development GO:0010977 ISS
    cell migration GO:0016477 ISS
    dentate gyrus development GO:0021542 ISS
    central nervous system neuron axonogenesis GO:0021955 ISS
    negative regulation of cell migration GO:0030336 IMP
    adult behavior GO:0030534 ISS
    regulation of protein stability GO:0031647 IMP
    central nervous system myelin maintenance GO:0032286 ISS
    negative regulation of peptidyl-serine phosphorylation GO:0033137 IMP
    multicellular organismal response to stress GO:0033555 ISS
    social behavior GO:0035176 ISS
    maternal behavior GO:0042711 ISS
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IBA
    locomotor rhythm GO:0045475 ISS
    negative regulation of osteoblast differentiation GO:0045668 IDA
    negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 IDA
    negative regulation of cell size GO:0045792 ISS
    negative regulation of organ growth GO:0046621 ISS
    phosphatidylinositol dephosphorylation GO:0046856 IBA
    phosphatidylinositol dephosphorylation GO:0046856 IDA
    phosphatidylinositol dephosphorylation GO:0046856 IMP
    forebrain morphogenesis GO:0048853 ISS
    cell motility GO:0048870 IBA
    negative regulation of axonogenesis GO:0050771 ISS
    protein stabilization GO:0050821 IDA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IMP
    negative regulation of keratinocyte migration GO:0051548 IMP
    negative regulation of focal adhesion assembly GO:0051895 IMP
    regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051896 IBA
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IDA
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IMP
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IMP
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISS
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 NAS
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 TAS
    rhythmic synaptic transmission GO:0060024 ISS
    canonical Wnt signaling pathway GO:0060070 IDA
    synapse maturation GO:0060074 ISS
    prepulse inhibition GO:0060134 ISS
    dendritic spine morphogenesis GO:0060997 ISS
    cellular response to electrical stimulus GO:0071257 IMP
    negative regulation of excitatory postsynaptic potential GO:0090394 ISS
    presynaptic membrane assembly GO:0097105 ISS
    postsynaptic density assembly GO:0097107 ISS
    negative regulation of cell cycle G1/S phase transition GO:1902807 IDA
    negative regulation of wound healing, spreading of epidermal cells GO:1903690 IMP
    positive regulation of ubiquitin protein ligase activity GO:1904668 IDA
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IMP
    positive regulation of ubiquitin-dependent protein catabolic process GO:2000060 IDA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IDA
    positive regulation of excitatory postsynaptic potential GO:2000463 ISS
    negative regulation of cellular senescence GO:2000773 ISS
    negative regulation of synaptic vesicle clustering GO:2000808 ISS
Subcellular Localization
    extracellular region GO:0005576 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    cytoplasmic side of plasma membrane GO:0009898 IDA
    postsynaptic density GO:0014069 IEA
    apical plasma membrane GO:0016324 IMP
    PML body GO:0016605 IEA
    myelin sheath adaxonal region GO:0035749 ISS
    cell projection GO:0042995 IBA
    cell projection GO:0042995 IDA
    neuron projection GO:0043005 ISS
    dendritic spine GO:0043197 IEA
    Schmidt-Lanterman incisure GO:0043220 ISS
 Experiment description of studies that identified PTEN in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTEN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIRT4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 FRK 2444
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 MVP 9961
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
4 DBF4B 80174
Affinity Capture-MS Homo sapiens
5 IFIH1  
Synthetic Growth Defect Homo sapiens
6 AFG3L2 10939
Affinity Capture-MS Homo sapiens
7 SMARCB1 6598
Negative Genetic Homo sapiens
8 CCNE2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
9 PPP3CA 5530
Affinity Capture-Western Homo sapiens
10 OSBP2  
Synthetic Growth Defect Homo sapiens
11 ELL2 22936
Negative Genetic Homo sapiens
12 PPP2R4 5524
Affinity Capture-Western Homo sapiens
13 XIAP  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
14 POLM  
Synthetic Growth Defect Homo sapiens
15 HPSE2  
Affinity Capture-MS Homo sapiens
16 FBN2 2201
Affinity Capture-MS Homo sapiens
17 CSK 1445
Negative Genetic Homo sapiens
18 SRGAP1 57522
Affinity Capture-MS Homo sapiens
19 WWP1 11059
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
20 USP13  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
21 MTOR 2475
Negative Genetic Homo sapiens
22 XPC  
Affinity Capture-MS Homo sapiens
23 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
24 ANAPC5 51433
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
25 CENPC  
Affinity Capture-MS Homo sapiens
26 GPC1 2817
Affinity Capture-MS Homo sapiens
27 PBK  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
28 HES5  
Synthetic Growth Defect Homo sapiens
29 SOCS1  
Synthetic Growth Defect Homo sapiens
30 UBC 7316
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
31 KDM6A  
Positive Genetic Homo sapiens
32 VHL  
Negative Genetic Homo sapiens
33 STK36  
Affinity Capture-MS Homo sapiens
34 PARK7 11315
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
35 PDHA1 5160
Affinity Capture-MS Homo sapiens
36 PBX3  
Synthetic Growth Defect Homo sapiens
37 CAPRIN2  
Affinity Capture-MS Homo sapiens
38 PCDHGA10  
Affinity Capture-MS Homo sapiens
39 OTUD3 23252
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
40 CARS2 79587
Synthetic Growth Defect Homo sapiens
41 AMHR2  
Affinity Capture-MS Homo sapiens
42 BLOC1S1  
Synthetic Growth Defect Homo sapiens
43 IGSF10 285313
Affinity Capture-MS Homo sapiens
44 PIGN 23556
Synthetic Growth Defect Homo sapiens
45 MAGI3 260425
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
46 ARMC2  
Affinity Capture-MS Homo sapiens
47 UBL7  
Affinity Capture-MS Homo sapiens
48 RAMP2  
Affinity Capture-MS Homo sapiens
49 G3BP2 9908
Affinity Capture-MS Homo sapiens
50 ACAP2 23527
Affinity Capture-MS Homo sapiens
51 EGR1  
Affinity Capture-Western Homo sapiens
52 COPS6 10980
Two-hybrid Homo sapiens
53 USP39 10713
Affinity Capture-MS Homo sapiens
54 CENPL  
Affinity Capture-MS Homo sapiens
55 HES6  
Synthetic Growth Defect Homo sapiens
56 FZR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
57 SMTN 6525
Affinity Capture-MS Homo sapiens
58 TBC1D31  
Affinity Capture-MS Homo sapiens
59 SUV39H1  
Synthetic Growth Defect Homo sapiens
60 MDC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
61 FSBP  
Affinity Capture-MS Homo sapiens
62 C2CD4C  
Affinity Capture-MS Homo sapiens
63 RHOA 387
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 RAD51  
Affinity Capture-Western Homo sapiens
65 ARID1A 8289
Negative Genetic Homo sapiens
66 CEP162  
Affinity Capture-MS Homo sapiens
67 CHGB 1114
Two-hybrid Homo sapiens
68 PTK7 5754
Two-hybrid Homo sapiens
69 PTPN14 5784
Affinity Capture-MS Homo sapiens
70 ANAPC7 51434
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
71 SNED1  
Affinity Capture-MS Homo sapiens
72 PPAP2B 8613
Synthetic Growth Defect Homo sapiens
73 ZSCAN18  
Affinity Capture-MS Homo sapiens
74 RNF126  
Affinity Capture-Western Homo sapiens
75 PKN2 5586
Affinity Capture-MS Homo sapiens
76 CLNK  
Affinity Capture-MS Homo sapiens
77 USP7 7874
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
78 CEP131 22994
Affinity Capture-MS Homo sapiens
79 NEDD4 4734
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
80 P3H4 10609
Affinity Capture-MS Homo sapiens
81 EXOC5 10640
Affinity Capture-MS Homo sapiens
82 DVL2 1856
Affinity Capture-MS Homo sapiens
83 USPL1  
Negative Genetic Homo sapiens
84 KIAA0196 9897
Synthetic Growth Defect Homo sapiens
85 TRIM8  
Synthetic Growth Defect Homo sapiens
86 TCL1B  
Affinity Capture-MS Homo sapiens
87 NFU1 27247
Negative Genetic Homo sapiens
88 RASSF2 9770
Synthetic Growth Defect Homo sapiens
89 TMCO6  
Negative Genetic Homo sapiens
90 NDFIP1 80762
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
91 CA11  
Negative Genetic Homo sapiens
92 SHROOM3 57619
Affinity Capture-MS Homo sapiens
93 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
94 PPP1CA 5499
Affinity Capture-Western Homo sapiens
95 LINC01198  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
96 BCAR1 9564
Reconstituted Complex Homo sapiens
97 ANG 283
Two-hybrid Homo sapiens
98 IDE 3416
Affinity Capture-Western Homo sapiens
99 UTP14A 10813
Two-hybrid Homo sapiens
100 SPTA1  
Affinity Capture-MS Homo sapiens
101 TNKS 8658
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
102 USP10 9100
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
103 CHMP4BP1 100307126
Affinity Capture-MS Homo sapiens
104 PSMD4 5710
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
105 ITGA6 3655
Affinity Capture-MS Homo sapiens
106 LUZP1 7798
Affinity Capture-MS Homo sapiens
107 PARK2  
Affinity Capture-MS Homo sapiens
108 WHSC1 7468
Affinity Capture-Western Homo sapiens
109 PDGFRB 5159
Co-localization Homo sapiens
110 ERBB3 2065
Two-hybrid Homo sapiens
111 NCOR2  
Affinity Capture-MS Homo sapiens
112 ADA 100
Positive Genetic Homo sapiens
113 MEX3C 51320
Affinity Capture-MS Homo sapiens
114 TUBA1A 7846
Synthetic Growth Defect Homo sapiens
115 UBAP2L 9898
Synthetic Growth Defect Homo sapiens
116 USP8 9101
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
117 CBL 867
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
118 TRIM24  
Synthetic Growth Defect Homo sapiens
119 RNF146  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
120 KRT39  
Affinity Capture-MS Homo sapiens
121 ZNF391  
Affinity Capture-MS Homo sapiens
122 UBE2I 7329
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 TCEB3C  
Affinity Capture-MS Homo sapiens
124 THBD 7056
Synthetic Growth Defect Homo sapiens
125 SMARCA4 6597
Negative Genetic Homo sapiens
126 SFMBT1 51460
Affinity Capture-MS Homo sapiens
127 NUMB 8650
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
128 TTBK2 146057
Affinity Capture-MS Homo sapiens
129 CRKL 1399
Affinity Capture-MS Homo sapiens
130 PTK2B 2185
Affinity Capture-MS Homo sapiens
131 SON 6651
Negative Genetic Homo sapiens
132 CHEK1  
Negative Genetic Homo sapiens
133 PLK1 5347
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
134 KRT14 3861
Affinity Capture-MS Homo sapiens
135 KIF11 3832
Affinity Capture-MS Homo sapiens
136 MEX3D  
Affinity Capture-MS Homo sapiens
137 GFRA2  
Affinity Capture-MS Homo sapiens
138 FNBP1 23048
Affinity Capture-MS Homo sapiens
139 ANAPC4 29945
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
140 BRAF  
Positive Genetic Homo sapiens
141 BRD4 23476
Negative Genetic Homo sapiens
142 DLC1 10395
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
143 YAP1 10413
Biochemical Activity Homo sapiens
144 SLC36A1 206358
Synthetic Growth Defect Homo sapiens
145 H2AFX 3014
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
146 TTC31  
Synthetic Growth Defect Homo sapiens
147 RFTN1 23180
Synthetic Growth Defect Homo sapiens
148 HBA1 3039
Two-hybrid Homo sapiens
149 DAXX  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
150 TXNDC11 51061
Synthetic Growth Defect Homo sapiens
151 TWIST1  
Biochemical Activity Homo sapiens
152 HEATR6  
Synthetic Growth Defect Homo sapiens
153 GPER1  
Synthetic Growth Defect Homo sapiens
154 NEDD1 121441
Affinity Capture-MS Homo sapiens
155 SCN10A 6336
Affinity Capture-MS Homo sapiens
156 UBE2S  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
157 PKMYT1  
Synthetic Growth Defect Homo sapiens
158 KRT3 3850
Affinity Capture-MS Homo sapiens
159 USP4 7375
Affinity Capture-MS Homo sapiens
160 CNOT4 4850
Negative Genetic Homo sapiens
161 NDUFC1  
Negative Genetic Homo sapiens
162 TP53BP1 7158
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
163 METTL16 79066
Affinity Capture-MS Homo sapiens
164 TPK1  
Affinity Capture-MS Homo sapiens
165 NDFIP2 54602
Affinity Capture-Western Homo sapiens
166 CDC27 996
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
167 RALB 5899
Affinity Capture-MS Homo sapiens
168 CDH3 1001
Affinity Capture-MS Homo sapiens
169 UBE2L3 7332
Affinity Capture-Western Homo sapiens
170 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
171 DLG1 1739
Reconstituted Complex Homo sapiens
172 PDGFRA 5156
Affinity Capture-MS Homo sapiens
173 RPL14 9045
Affinity Capture-MS Homo sapiens
174 PTEN 5728
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
175 DCAF13 25879
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
176 MXD1  
Synthetic Growth Defect Homo sapiens
177 LYRM1  
Affinity Capture-MS Homo sapiens
178 CSNK2A1 1457
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
179 MVB12A 93343
Negative Genetic Homo sapiens
180 TNKS2 80351
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
181 PTK2 5747
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
182 RAD54L 8438
Negative Genetic Homo sapiens
183 BAP1 8314
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
184 OPRL1 4987
Synthetic Growth Defect Homo sapiens
185 SNX27 81609
Affinity Capture-MS Homo sapiens
186 INS 3630
Biochemical Activity Homo sapiens
187 RPUSD1  
Affinity Capture-MS Homo sapiens
188 FSIP2 401024
Affinity Capture-MS Homo sapiens
189 SERPINB6 5269
Negative Genetic Homo sapiens
190 MAP2K6 5608
Affinity Capture-MS Homo sapiens
191 BIRC6 57448
Affinity Capture-MS Homo sapiens
192 Smurf2  
Affinity Capture-Luminescence Mus musculus
193 CAV1 857
Affinity Capture-Western Homo sapiens
194 YME1L1 10730
Synthetic Growth Defect Homo sapiens
195 PTPN13 5783
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 CMTM1  
Affinity Capture-MS Homo sapiens
197 CNTROB  
Affinity Capture-MS Homo sapiens
198 EGFR 1956
Affinity Capture-Western Homo sapiens
199 CSNK2A2 1459
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
200 CDC42EP5  
Synthetic Growth Defect Homo sapiens
201 EEFSEC 60678
Affinity Capture-MS Homo sapiens
202 EEF1A2 1917
Affinity Capture-MS Homo sapiens
203 MET 4233
Positive Genetic Homo sapiens
204 BBX 56987
Affinity Capture-MS Homo sapiens
205 ENO2 2026
Synthetic Growth Defect Homo sapiens
206 NRCAM  
Affinity Capture-MS Homo sapiens
207 BMI1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
208 ST8SIA6  
Synthetic Growth Defect Homo sapiens
209 AKT1 207
Affinity Capture-Western Homo sapiens
210 FSCN1 6624
Affinity Capture-MS Homo sapiens
211 GPR113  
Affinity Capture-MS Homo sapiens
212 RPRD1B 58490
Negative Genetic Homo sapiens
213 ZER1 10444
Affinity Capture-MS Homo sapiens
214 PIK3R1 5295
FRET Homo sapiens
215 ZNF787  
Affinity Capture-MS Homo sapiens
216 SNAI1  
Biochemical Activity Homo sapiens
217 SLC12A2 6558
Affinity Capture-MS Homo sapiens
218 CFB 629
Synthetic Growth Defect Homo sapiens
219 UBE2D1 7321
Synthetic Growth Defect Homo sapiens
220 IQCF2  
Affinity Capture-MS Homo sapiens
221 STUB1 10273
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
222 QRFPR  
Affinity Capture-MS Homo sapiens
223 PSMB2 5690
Synthetic Growth Defect Homo sapiens
224 PDZD9  
Affinity Capture-MS Homo sapiens
225 LLGL2 3993
Synthetic Growth Defect Homo sapiens
226 INHBE 83729
Affinity Capture-MS Homo sapiens
227 AATK  
Two-hybrid Homo sapiens
228 SPOP  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
229 ATRX 546
Affinity Capture-MS Homo sapiens
230 HAGHL  
Synthetic Growth Defect Homo sapiens
231 SLC25A6 293
Synthetic Growth Defect Homo sapiens
232 KDELR1 10945
Negative Genetic Homo sapiens
233 GRB2 2885
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
234 TDRD15  
Affinity Capture-MS Homo sapiens
235 FBXL6  
Synthetic Growth Defect Homo sapiens
236 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
237 SCYL2 55681
Affinity Capture-MS Homo sapiens
238 CCDC7  
Affinity Capture-MS Homo sapiens
239 USP1 7398
Negative Genetic Homo sapiens
240 LINC00839  
Protein-RNA Homo sapiens
241 PIGH  
Negative Genetic Homo sapiens
242 HDAC6 10013
Affinity Capture-MS Homo sapiens
243 KAT2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
244 RPA1 6117
Affinity Capture-MS Homo sapiens
245 SPATA18  
Affinity Capture-MS Homo sapiens
246 WNT4  
Affinity Capture-MS Homo sapiens
247 EME2 197342
Synthetic Growth Defect Homo sapiens
248 CASP8 841
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
249 RPTOR 57521
Affinity Capture-MS Homo sapiens
250 SMURF1 57154
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
251 RIOK1 83732
Affinity Capture-MS Homo sapiens
252 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
253 PLEKHA1 59338
Proximity Label-MS Homo sapiens
254 HSP90AA1 3320
Positive Genetic Homo sapiens
255 RYR3 6263
Affinity Capture-MS Homo sapiens
256 CREB1  
Biochemical Activity Homo sapiens
257 P2RY11  
Affinity Capture-MS Homo sapiens
258 TRIM25 7706
Biochemical Activity Homo sapiens
259 ESR1  
Reconstituted Complex Homo sapiens
260 ZC3H15 55854
Affinity Capture-MS Homo sapiens
261 NF1 4763
Positive Genetic Homo sapiens
262 WWP2 11060
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
263 TSGA10  
Affinity Capture-MS Homo sapiens
264 TRIM37  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
265 NOC2L 26155
Affinity Capture-MS Homo sapiens
266 MED12  
Affinity Capture-MS Homo sapiens
267 ITGB7 3695
Affinity Capture-MS Homo sapiens
268 PARD6B 84612
Negative Genetic Homo sapiens
269 CDK4 1019
Positive Genetic Homo sapiens
270 ARRB1 408
Affinity Capture-MS Homo sapiens
271 PXN 5829
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
272 PINK1  
Affinity Capture-MS Homo sapiens
273 SLC9A3R1 9368
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
274 CYB5R3 1727
Synthetic Growth Defect Homo sapiens
275 UBAC2 337867
Affinity Capture-MS Homo sapiens
276 ANKRD11 29123
Affinity Capture-MS Homo sapiens
277 RPS27A 6233
Affinity Capture-MS Homo sapiens
278 SHARPIN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
279 PIK3R2 5296
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
280 TOPAZ1  
Affinity Capture-MS Homo sapiens
281 COX6B2  
Negative Genetic Homo sapiens
282 TYMS 7298
Negative Genetic Homo sapiens
283 AR 367
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
284 STAMBP 10617
Negative Genetic Homo sapiens
285 FAM106A  
Negative Genetic Homo sapiens
286 ZC3H7A  
Negative Genetic Homo sapiens
287 C16orf71  
Affinity Capture-MS Homo sapiens
288 IRS4 8471
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
289 NGB  
Reconstituted Complex Homo sapiens
290 ZNF318 24149
Affinity Capture-MS Homo sapiens
291 RBCK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
292 DGKZ  
Affinity Capture-MS Homo sapiens
293 NOTCH1 4851
Synthetic Growth Defect Homo sapiens
294 CDKN2A 1029
Positive Genetic Homo sapiens
View the network image/svg+xml
 Pathways in which PTEN is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Deubiquitination TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream TCR signaling TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Immune System TAS Reactome
Inositol phosphate metabolism TAS Reactome
Intracellular signaling by second messengers TAS Reactome
Metabolism TAS Reactome
Metabolism of lipids TAS Reactome
Metabolism of proteins TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Ovarian tumor domain proteases TAS Reactome
Phospholipid metabolism TAS Reactome
PI Metabolism TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Post-translational protein modification TAS Reactome
PTEN Loss of Function in Cancer TAS Reactome
PTEN Regulation TAS Reactome
Regulation of PTEN localization TAS Reactome
Regulation of PTEN mRNA translation TAS Reactome
Regulation of PTEN stability and activity TAS Reactome
RNA Polymerase II Transcription TAS Reactome
Signal Transduction TAS Reactome
Synthesis of IP3 and IP4 in the cytosol TAS Reactome
Synthesis of PIPs at the plasma membrane TAS Reactome
TCR signaling TAS Reactome
TP53 Regulates Metabolic Genes TAS Reactome
Transcriptional Regulation by MECP2 TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Ub-specific processing proteases TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here