Gene description for SCN10A
Gene name sodium channel, voltage gated, type X alpha subunit
Gene symbol SCN10A
Other names/aliases FEPS2
Nav1.8
PN3
SNS
hPN3
Species Homo sapiens
 Database cross references - SCN10A
ExoCarta ExoCarta_6336
Vesiclepedia VP_6336
Entrez Gene 6336
HGNC 10582
MIM 604427
UniProt Q9Y5Y9  
 SCN10A identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for SCN10A
Molecular Function
    voltage-gated sodium channel activity GO:0005248 IBA
    voltage-gated sodium channel activity GO:0005248 IDA
    voltage-gated sodium channel activity GO:0005248 IMP
    transmembrane transporter binding GO:0044325 IPI
    voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099508 IEA
Biological Process
    regulation of heart rate GO:0002027 IMP
    sensory perception GO:0007600 TAS
    regulation of monoatomic ion transmembrane transport GO:0034765 IDA
    sodium ion transmembrane transport GO:0035725 IBA
    sodium ion transmembrane transport GO:0035725 IDA
    odontogenesis of dentin-containing tooth GO:0042475 IEA
    regulation of cardiac muscle contraction GO:0055117 IMP
    regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 IMP
    cardiac muscle cell action potential involved in contraction GO:0086002 IBA
    membrane depolarization during action potential GO:0086010 IMP
    AV node cell action potential GO:0086016 IMP
    bundle of His cell action potential GO:0086043 IMP
    regulation of presynaptic membrane potential GO:0099505 IEA
Subcellular Localization
    voltage-gated sodium channel complex GO:0001518 IBA
    voltage-gated sodium channel complex GO:0001518 IDA
    plasma membrane GO:0005886 IDA
    axon GO:0030424 ISS
    presynaptic membrane GO:0042734 IEA
    extracellular exosome GO:0070062 HDA
    clathrin complex GO:0071439 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified SCN10A in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SCN10A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTEN 5728
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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