Gene description for ARRB1
Gene name arrestin, beta 1
Gene symbol ARRB1
Other names/aliases ARB1
ARR1
Species Homo sapiens
 Database cross references - ARRB1
ExoCarta ExoCarta_408
Vesiclepedia VP_408
Entrez Gene 408
HGNC 711
MIM 107940
UniProt P49407  
 ARRB1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ARRB1
Molecular Function
    G protein-coupled receptor binding GO:0001664 IBA
    transcription coactivator activity GO:0003713 IMP
    histone acetyltransferase activity GO:0004402 IDA
    enzyme inhibitor activity GO:0004857 TAS
    GTPase activator activity GO:0005096 IMP
    insulin-like growth factor receptor binding GO:0005159 IPI
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    angiotensin receptor binding GO:0031701 IPI
    arrestin family protein binding GO:1990763 IPI
Biological Process
    positive regulation of protein phosphorylation GO:0001934 IMP
    G protein-coupled receptor internalization GO:0002031 IBA
    G protein-coupled receptor internalization GO:0002031 IMP
    positive regulation of receptor internalization GO:0002092 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IMP
    ubiquitin-dependent protein catabolic process GO:0006511 IMP
    signal transduction GO:0007165 IEA
    protein transport GO:0015031 IEA
    protein ubiquitination GO:0016567 IMP
    negative regulation of protein ubiquitination GO:0031397 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    negative regulation of interleukin-6 production GO:0032715 IDA
    negative regulation of interleukin-8 production GO:0032717 IDA
    positive regulation of Rho protein signal transduction GO:0035025 IMP
    stress fiber assembly GO:0043149 IMP
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMP
    negative regulation of Notch signaling pathway GO:0045746 IBA
    negative regulation of Notch signaling pathway GO:0045746 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IBA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    chromatin GO:0000785 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    lysosomal membrane GO:0005765 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    clathrin-coated pit GO:0005905 IEA
    nuclear body GO:0016604 IDA
    cytoplasmic vesicle membrane GO:0030659 TAS
    endocytic vesicle membrane GO:0030666 TAS
    pseudopodium GO:0031143 IEA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified ARRB1 in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 834
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 835
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ARRB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
2 ADRBK1 156
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-localization Homo sapiens
3 P4HB 5034
Affinity Capture-MS Homo sapiens
4 APLP1 333
Affinity Capture-MS Homo sapiens
5 C5AR1  
Affinity Capture-Western Homo sapiens
6 GNMT 27232
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
7 ATR  
Affinity Capture-MS Homo sapiens
8 KPNA3 3839
Affinity Capture-MS Homo sapiens
9 DNAH3 55567
Affinity Capture-MS Homo sapiens
10 RAB1A 5861
Affinity Capture-MS Homo sapiens
11 POT1  
Two-hybrid Homo sapiens
12 DOCK4 9732
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 CSK 1445
Affinity Capture-Western Homo sapiens
14 RPS17 6218
Affinity Capture-MS Homo sapiens
15 CPA1 1357
Affinity Capture-MS Homo sapiens
16 USP24 23358
Affinity Capture-MS Homo sapiens
17 YWHAE 7531
Affinity Capture-MS Homo sapiens
18 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
19 G3BP1 10146
Affinity Capture-MS Homo sapiens
20 MIIP 60672
Affinity Capture-MS Homo sapiens
21 KHK 3795
Affinity Capture-MS Homo sapiens
22 ADRB1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
23 UBC 7316
Affinity Capture-MS Homo sapiens
24 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
25 DRD4  
Affinity Capture-Western Homo sapiens
26 CYTH2 9266
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
27 CFL1 1072
Affinity Capture-MS Homo sapiens
28 RPL22 6146
Affinity Capture-MS Homo sapiens
29 CMBL 134147
Affinity Capture-MS Homo sapiens
30 MAPK10 5602
Affinity Capture-Western Homo sapiens
31 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
32 APEX1 328
Affinity Capture-RNA Homo sapiens
33 YES1 7525
Affinity Capture-MS Homo sapiens
34 MAP3K5 4217
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
35 INA 9118
Affinity Capture-MS Homo sapiens
36 YWHAZ 7534
Affinity Capture-MS Homo sapiens
37 RPL7A 6130
Affinity Capture-MS Homo sapiens
38 IGHMBP2 3508
Affinity Capture-MS Homo sapiens
39 TUBB 203068
Affinity Capture-MS Homo sapiens
40 SLC9A5  
Affinity Capture-Western Homo sapiens
41 NOLC1 9221
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 H1FX 8971
Affinity Capture-MS Homo sapiens
43 SPIN1  
Affinity Capture-MS Homo sapiens
44 HGS 9146
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
45 DGKE  
Affinity Capture-MS Homo sapiens
46 SUPV3L1 6832
Co-fractionation Homo sapiens
47 ALPK2  
Affinity Capture-MS Homo sapiens
48 Naa10  
Affinity Capture-MS Mus musculus
49 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 SRRM2 23524
Affinity Capture-MS Homo sapiens
51 S100A9 6280
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
52 NPM1 4869
Affinity Capture-MS Homo sapiens
53 YWHAG 7532
Affinity Capture-MS Homo sapiens
54 DMD 1756
Affinity Capture-MS Homo sapiens
55 CALM3 808
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
56 CXCR2  
Affinity Capture-Western Homo sapiens
57 PPM1A 5494
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
58 USP33  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
59 Chrna4  
Affinity Capture-Western Mus musculus
Affinity Capture-Western Mus musculus
60 YWHAH 7533
Affinity Capture-MS Homo sapiens
61 ELMO2 63916
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
63 POLR1E  
Affinity Capture-MS Homo sapiens
64 DNM1 1759
Affinity Capture-MS Homo sapiens
65 LRP4 4038
Affinity Capture-MS Homo sapiens
66 TNFRSF1B  
Affinity Capture-MS Homo sapiens
67 NEDD4 4734
Affinity Capture-Western Homo sapiens
68 MAP3K1 4214
Affinity Capture-MS Homo sapiens
69 HIST2H4A 8370
Affinity Capture-MS Homo sapiens
70 DVL2 1856
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
71 GSK3B 2932
Biochemical Activity Homo sapiens
72 RALGDS  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
73 PES1 23481
Affinity Capture-MS Homo sapiens
74 KIF2C 11004
Affinity Capture-MS Homo sapiens
75 Trhr  
FRET Rattus norvegicus
76 CHD1 1105
Affinity Capture-MS Homo sapiens
77 MAPK1 5594
Biochemical Activity Homo sapiens
78 PPM1B 5495
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
79 BRPF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 TCOF1 6949
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
81 ATP5A1 498
Affinity Capture-MS Homo sapiens
82 CALD1 800
Affinity Capture-MS Homo sapiens
83 MAPK3 5595
Biochemical Activity Homo sapiens
84 PKM 5315
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
85 OPRD1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
86 DHRS2 10202
Affinity Capture-MS Homo sapiens
87 ARRDC1 92714
Affinity Capture-Western Homo sapiens
88 PARK2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
89 IGF1R 3480
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 HIST1H2AG 8969
Affinity Capture-MS Homo sapiens
91 ACIN1 22985
Affinity Capture-MS Homo sapiens
92 RTF1 23168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 ACTA1 58
Affinity Capture-MS Homo sapiens
94 ACACA 31
Affinity Capture-MS Homo sapiens
95 RGS3 5998
Affinity Capture-MS Homo sapiens
96 PRDM16 63976
Two-hybrid Homo sapiens
97 SNRPD1 6632
Affinity Capture-MS Homo sapiens
98 SREBF2 6721
Two-hybrid Homo sapiens
99 MYH9 4627
Affinity Capture-MS Homo sapiens
100 PFKFB3 5209
Affinity Capture-MS Homo sapiens
101 CCR5 1234
Reconstituted Complex Homo sapiens
102 SLC9A1 6548
Affinity Capture-Western Homo sapiens
103 LYRM7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 XRCC5 7520
Affinity Capture-MS Homo sapiens
105 ENAH 55740
Co-fractionation Homo sapiens
106 KIAA1143  
Co-fractionation Homo sapiens
107 ARRDC3 57561
Affinity Capture-Western Homo sapiens
108 POLR2E 5434
Affinity Capture-MS Homo sapiens
109 TUBA1C 84790
Affinity Capture-MS Homo sapiens
110 BTK 695
Two-hybrid Homo sapiens
111 AP3B1 8546
Affinity Capture-MS Homo sapiens
112 RAB11FIP5 26056
Affinity Capture-MS Homo sapiens
113 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
114 MAGEB2 4113
Affinity Capture-MS Homo sapiens
115 ANKRD44 91526
Affinity Capture-MS Homo sapiens
116 LRP1B 53353
Affinity Capture-MS Homo sapiens
117 BACH2 60468
Affinity Capture-MS Homo sapiens
118 DDX27 55661
Affinity Capture-MS Homo sapiens
119 TUBA4A 7277
Affinity Capture-MS Homo sapiens
120 EIF3I 8668
Affinity Capture-MS Homo sapiens
121 HCRTR1  
FRET Homo sapiens
122 ZBTB43  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
123 KBTBD8  
Affinity Capture-Western Homo sapiens
124 STAM 8027
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
125 RBM10  
Affinity Capture-MS Homo sapiens
126 CD3EAP  
Affinity Capture-MS Homo sapiens
127 TUBA3C 7278
Affinity Capture-MS Homo sapiens
128 BCLAF1 9774
Affinity Capture-MS Homo sapiens
129 TTN 7273
Affinity Capture-MS Homo sapiens
130 LIMA1 51474
Affinity Capture-MS Homo sapiens
131 MAPK9 5601
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
132 TMPO 7112
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
133 SDC3  
Affinity Capture-MS Homo sapiens
134 STXBP5 134957
Affinity Capture-MS Homo sapiens
135 DGKG  
Affinity Capture-MS Homo sapiens
136 RPS2 6187
Affinity Capture-MS Homo sapiens
137 SF3B2 10992
Affinity Capture-MS Homo sapiens
138 PDE4D  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
139 ARRDC4  
Affinity Capture-Western Homo sapiens
140 CSN2 1447
Affinity Capture-MS Homo sapiens
141 YBX1 4904
Affinity Capture-MS Homo sapiens
142 PTCH2  
Affinity Capture-MS Homo sapiens
143 NFKBIA  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
144 NAA15 80155
Affinity Capture-MS Homo sapiens
145 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
146 CUL3 8452
Affinity Capture-Western Homo sapiens
147 PTEN 5728
Affinity Capture-MS Homo sapiens
148 CTTN 2017
Affinity Capture-MS Homo sapiens
149 RPL3 6122
Affinity Capture-MS Homo sapiens
150 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-Luminescence Homo sapiens
151 RPL8 6132
Affinity Capture-MS Homo sapiens
152 YY1 7528
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
153 ARF6 382
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
154 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
155 MAP1B 4131
Affinity Capture-MS Homo sapiens
156 RPL7L1 285855
Affinity Capture-MS Homo sapiens
157 DVL1 1855
Affinity Capture-Western Homo sapiens
158 MYO1C 4641
Affinity Capture-MS Homo sapiens
159 HIST1H2BO 8348
Affinity Capture-MS Homo sapiens
160 CDC42 998
Two-hybrid Homo sapiens
161 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
162 JUN 3725
Two-hybrid Homo sapiens
163 RANBP9 10048
Affinity Capture-MS Homo sapiens
164 PRMT5 10419
Affinity Capture-MS Homo sapiens
165 DGKZ  
Affinity Capture-MS Homo sapiens
166 DKC1 1736
Affinity Capture-MS Homo sapiens
167 SAG 6295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 BAG1 573
Two-hybrid Homo sapiens
169 JAK1 3716
Affinity Capture-MS Homo sapiens
170 VIM 7431
Affinity Capture-MS Homo sapiens
171 KCTD3  
Affinity Capture-MS Homo sapiens
172 SLC2A14 144195
Affinity Capture-MS Homo sapiens
173 TMOD3 29766
Affinity Capture-MS Homo sapiens
174 Mlnr  
FRET Rattus norvegicus
175 PRPF4 9128
Affinity Capture-Western Homo sapiens
176 EEF1A2 1917
Affinity Capture-MS Homo sapiens
177 H3F3B 3021
Affinity Capture-MS Homo sapiens
178 HDLBP 3069
Affinity Capture-MS Homo sapiens
179 KTN1 3895
Affinity Capture-MS Homo sapiens
180 DGKH 160851
Affinity Capture-MS Homo sapiens
181 CLTC 1213
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
182 KIF3A 11127
Affinity Capture-MS Homo sapiens
183 MPRIP 23164
Affinity Capture-MS Homo sapiens
184 HSPA9 3313
Affinity Capture-MS Homo sapiens
185 KIF26A 26153
Affinity Capture-MS Homo sapiens
186 CPNE8 144402
Affinity Capture-MS Homo sapiens
187 ROCK1 6093
Affinity Capture-MS Homo sapiens
188 BRD3 8019
Affinity Capture-MS Homo sapiens
189 TPM4 7171
Affinity Capture-MS Homo sapiens
190 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
191 RPL15 6138
Two-hybrid Homo sapiens
192 ADH6 130
Two-hybrid Homo sapiens
193 PTAFR  
Affinity Capture-Western Homo sapiens
194 H2AFX 3014
Affinity Capture-MS Homo sapiens
195 STUB1 10273
Affinity Capture-Western Homo sapiens
196 GSN 2934
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
197 HIST2H2AB 317772
Affinity Capture-MS Homo sapiens
198 TUBB2A 7280
Affinity Capture-MS Homo sapiens
199 RPL13 6137
Affinity Capture-MS Homo sapiens
200 NSF 4905
Affinity Capture-Western Homo sapiens
201 SNCA 6622
Affinity Capture-Western Homo sapiens
202 ARHGEF18 23370
Co-fractionation Homo sapiens
203 RPS27A 6233
Affinity Capture-MS Homo sapiens
204 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 GNG2 54331
Affinity Capture-Western Homo sapiens
206 FASN 2194
Affinity Capture-MS Homo sapiens
207 SPTAN1 6709
Affinity Capture-MS Homo sapiens
208 ARPC5 10092
Affinity Capture-MS Homo sapiens
209 EDNRA 1909
Affinity Capture-Western Homo sapiens
210 MYL6 4637
Affinity Capture-MS Homo sapiens
211 CCL14  
Affinity Capture-MS Homo sapiens
212 ALDH4A1 8659
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
213 WDR77 79084
Affinity Capture-MS Homo sapiens
214 ZRANB2 9406
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
215 RPL6 6128
Affinity Capture-MS Homo sapiens
216 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
217 SCYL2 55681
Affinity Capture-MS Homo sapiens
218 NEK6 10783
Two-hybrid Homo sapiens
219 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
220 HSPA7 3311
Affinity Capture-MS Homo sapiens
221 STK38 11329
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
222 POLR1C 9533
Affinity Capture-MS Homo sapiens
223 DPY30 84661
Affinity Capture-MS Homo sapiens
224 BOP1 23246
Affinity Capture-MS Homo sapiens
225 ATP5B 506
Affinity Capture-MS Homo sapiens
226 ARR3 407
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
227 KLHL12  
Affinity Capture-Western Homo sapiens
228 HNRNPM 4670
Affinity Capture-MS Homo sapiens
229 YWHAB 7529
Affinity Capture-MS Homo sapiens
230 THRAP3 9967
Affinity Capture-MS Homo sapiens
231 ITCH 83737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
232 CYTH1 9267
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
233 NOP10 55505
Affinity Capture-MS Homo sapiens
234 STK38L 23012
Affinity Capture-MS Homo sapiens
235 GNB1 2782
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
236 MYH1  
Affinity Capture-MS Homo sapiens
237 AXIN1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
238 ARHGAP32  
Affinity Capture-MS Homo sapiens
239 HNRNPK 3190
Affinity Capture-MS Homo sapiens
240 POLR1A 25885
Affinity Capture-MS Homo sapiens
241 POU2F1 5451
Two-hybrid Homo sapiens
242 GPR50  
FRET Homo sapiens
243 PPM1H  
Co-fractionation Homo sapiens
244 UBB 7314
Affinity Capture-MS Homo sapiens
245 RPS3A 6189
Affinity Capture-MS Homo sapiens
246 NOTCH1 4851
Affinity Capture-Western Homo sapiens
247 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
248 ZYX 7791
Affinity Capture-MS Homo sapiens
249 NCL 4691
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
250 ALYREF 10189
Affinity Capture-MS Homo sapiens
251 EIF4B 1975
Affinity Capture-MS Homo sapiens
252 IGF2BP2 10644
Affinity Capture-MS Homo sapiens
253 FLNA 2316
Affinity Capture-MS Homo sapiens
254 CLTA 1211
Affinity Capture-MS Homo sapiens
255 RPS8 6202
Affinity Capture-MS Homo sapiens
256 HIBCH 26275
Affinity Capture-MS Homo sapiens
257 CNGA3  
Affinity Capture-MS Homo sapiens
258 Agtr1a  
Affinity Capture-Western Rattus norvegicus
259 PIK3R2 5296
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
260 HNRNPU 3192
Affinity Capture-MS Homo sapiens
261 ANXA2 302
Affinity Capture-MS Homo sapiens
262 CKAP4 10970
Affinity Capture-MS Homo sapiens
263 AP3D1 8943
Affinity Capture-MS Homo sapiens
264 HSPA5 3309
Affinity Capture-MS Homo sapiens
265 PTGER4  
Affinity Capture-Western Homo sapiens
266 PTHLH  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
267 HSPA1B 3304
Affinity Capture-MS Homo sapiens
268 DCAF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
269 SEC31A 22872
Co-fractionation Homo sapiens
270 MYL12B 103910
Affinity Capture-MS Homo sapiens
271 UBA52 7311
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ARRB1 is involved
PathwayEvidenceSource
Activated NOTCH1 Transmits Signal to the Nucleus IEA Reactome
Activation of SMO TAS Reactome
Activation of SMO IEA Reactome
Cargo recognition for clathrin-mediated endocytosis TAS Reactome
Clathrin-mediated endocytosis TAS Reactome
Deubiquitination TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
G alpha (s) signalling events TAS Reactome
Golgi Associated Vesicle Biogenesis TAS Reactome
GPCR downstream signalling TAS Reactome
Hedgehog 'on' state TAS Reactome
Hedgehog 'on' state IEA Reactome
Hemostasis TAS Reactome
Lysosome Vesicle Biogenesis TAS Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Membrane Trafficking TAS Reactome
Metabolism of proteins TAS Reactome
Oncogenic MAPK signaling TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Post-translational protein modification TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by Hedgehog TAS Reactome
Signaling by Hedgehog IEA Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFBR3 TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
TGFBR3 regulates TGF-beta signaling TAS Reactome
Thrombin signalling through proteinase activated receptors (PARs) TAS Reactome
trans-Golgi Network Vesicle Budding TAS Reactome
Ub-specific processing proteases TAS Reactome
Vesicle-mediated transport TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here